Remimazolam in a Pediatric Patient With a Suspected Family History of Malignant Hyperthermia

Overview

Journal J Med Cases

Specialty General Medicine

Date 2022 Sep 21

PMID 36128061

Authors

Holly Petkus

Brittany L Willer

Joseph D Tobias

Affiliations

Soon will be listed here.

Abstract

Malignant hyperthermia (MH) is an acute hypermetabolic crisis, triggered in susceptible patients by the administration of succinylcholine or a volatile anesthetic agent. When providing anesthetic care for MH-susceptible patients, a total intravenous anesthetic technique with propofol or other sedative hypnotic is frequently chosen. Remimazolam is a novel benzodiazepine which, like midazolam, has sedative, anxiolytic, and amnestic properties. Ester metabolism results in a half-life of 5-10 min and a limited context sensitive half-life. We present anecdotal experience with its use as an adjunct to propofol anesthesia in a patient with a suspected family history of MH. Previous reports of the use of remimazolam in MH-susceptible patients are reviewed and its potential role in such patients discussed.

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