Safe Surgery for Glioblastoma: Recent Advances and Modern Challenges

Overview

Journal Neurooncol Pract

Publisher Oxford University Press

Date 2022 Sep 21

PMID 36127890

Authors

Jasper Kees Wim Gerritsen

Marike Lianne Daphne Broekman

Steven de Vleeschouwer

Philippe Schucht

Brian Vala Nahed

Mitchel Stuart Berger

Arnaud Jean Pierre Edouard Vincent

Affiliations

Soon will be listed here.

Abstract

One of the major challenges during glioblastoma surgery is balancing between maximizing extent of resection and preventing neurological deficits. Several surgical techniques and adjuncts have been developed to help identify eloquent areas both preoperatively (fMRI, nTMS, MEG, DTI) and intraoperatively (imaging (ultrasound, iMRI), electrostimulation (mapping), cerebral perfusion measurements (fUS)), and visualization (5-ALA, fluoresceine)). In this review, we give an update of the state-of-the-art management of both primary and recurrent glioblastomas. We will review the latest surgical advances, challenges, and approaches that define the onco-neurosurgical practice in a contemporary setting and give an overview of the current prospective scientific efforts.

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