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Safe Surgery for Glioblastoma: Recent Advances and Modern Challenges

Abstract

One of the major challenges during glioblastoma surgery is balancing between maximizing extent of resection and preventing neurological deficits. Several surgical techniques and adjuncts have been developed to help identify eloquent areas both preoperatively (fMRI, nTMS, MEG, DTI) and intraoperatively (imaging (ultrasound, iMRI), electrostimulation (mapping), cerebral perfusion measurements (fUS)), and visualization (5-ALA, fluoresceine)). In this review, we give an update of the state-of-the-art management of both primary and recurrent glioblastomas. We will review the latest surgical advances, challenges, and approaches that define the onco-neurosurgical practice in a contemporary setting and give an overview of the current prospective scientific efforts.

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References
1.
Roca E, Pallud J, Guerrini F, Panciani P, Fontanella M, Spena G . Stimulation-related intraoperative seizures during awake surgery: a review of available evidences. Neurosurg Rev. 2019; 43(1):87-93. DOI: 10.1007/s10143-019-01214-0. View

2.
McGirt M, Mukherjee D, Chaichana K, Than K, Weingart J, Quinones-Hinojosa A . Association of surgically acquired motor and language deficits on overall survival after resection of glioblastoma multiforme. Neurosurgery. 2009; 65(3):463-9. DOI: 10.1227/01.NEU.0000349763.42238.E9. View

3.
Kitange G, Carlson B, Schroeder M, Grogan P, Lamont J, Decker P . Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts. Neuro Oncol. 2008; 11(3):281-91. PMC: 2718972. DOI: 10.1215/15228517-2008-090. View

4.
Tarapore P, Tate M, Findlay A, Honma S, Mizuiri D, Berger M . Preoperative multimodal motor mapping: a comparison of magnetoencephalography imaging, navigated transcranial magnetic stimulation, and direct cortical stimulation. J Neurosurg. 2012; 117(2):354-62. PMC: 4060619. DOI: 10.3171/2012.5.JNS112124. View

5.
Picht T, Krieg S, Sollmann N, Rosler J, Niraula B, Neuvonen T . A comparison of language mapping by preoperative navigated transcranial magnetic stimulation and direct cortical stimulation during awake surgery. Neurosurgery. 2013; 72(5):808-19. DOI: 10.1227/NEU.0b013e3182889e01. View