Improvement of Memory Function Via a Combination of Exercise and Soy Peptide Supplementation in Community-dwelling Older Adults: A Randomized Controlled Trial

Overview

Journal Contemp Clin Trials Commun

Date 2022 Sep 20

PMID 36124312

Authors

Masakazu Imaoka

Hidetoshi Nakao

Misa Nakamura

Fumie Tazaki

Mitsumasa Hida

Ryota Imai

Motohiro Maebuchi

Masahisa Ibuki

Masatoshi Takeda

Affiliations

Soon will be listed here.

Abstract

Background: Soy peptide, when consumed as a functional food, has been reported to improve cognitive function. This study aimed to verify the combined effect of soy peptide supplementation and exercise on cognitive function among community-dwelling older adults in Japan.

Methods: In this population-based, non-blinded randomized controlled trial, 72 community-dwelling older adults who were independent in activities of daily living were randomly assigned to an "exercise plus nutrition" program (Ex + Nt group, n = 36) or an exercise program (Ex group, n = 36). For 3 months, both groups participated in an exercise and cognitive training regimen once per week, with the Ex + Nt group receiving soy supplementation once per week. Pre- and post-intervention measurements included grip strength, gait speed, skeletal muscle mass index, and scores on Addenbrooke's Cognitive Examination-Revised, trail-making test A, and the Geriatric Depression Scale. Participant enrollment for this study started in January 2019 and ended in April 2019.

Results: Exercise training increased the skeletal muscle mass index by 2.0% and 3.0% in the Ex + Nt and Ex groups, respectively. The Ex + Nt group exhibited a significant 0.3-point increase in the memory score.

Conclusion: A 3-month exercise program combined with soy peptide supplementation may be effective in improving both motor and memory function in community-dwelling older adults.

Citing Articles

Effects of Plant-Based Protein Interventions, with and without an Exercise Component, on Body Composition, Strength and Physical Function in Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Stoodley I, Williams L, Wood L Nutrients. 2023; 15(18).

PMID: 37764843 PMC: 10537483. DOI: 10.3390/nu15184060.

Association of depressive symptoms with Geriatric Locomotive Function Scale score in community-dwelling older adults living in the state of emergency.

Imaoka M, Nakamura M, Tasaki F, Inoue T, Orui J, Imai R BMC Geriatr. 2023; 23(1):341.

PMID: 37259068 PMC: 10231278. DOI: 10.1186/s12877-023-04077-9.

References

Karp A, Kareholt I, Qiu C, Bellander T, Winblad B, Fratiglioni L . Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease. Am J Epidemiol. 2004; 159(2):175-83. DOI: 10.1093/aje/kwh018. View

Kim H, Suzuki T, Saito K, Yoshida H, Kojima N, Kim M . Effects of exercise and tea catechins on muscle mass, strength and walking ability in community-dwelling elderly Japanese sarcopenic women: a randomized controlled trial. Geriatr Gerontol Int. 2012; 13(2):458-65. DOI: 10.1111/j.1447-0594.2012.00923.x. View

Mathai J, Liu Y, Stein H . Values for digestible indispensable amino acid scores (DIAAS) for some dairy and plant proteins may better describe protein quality than values calculated using the concept for protein digestibility-corrected amino acid scores (PDCAAS). Br J Nutr. 2017; 117(4):490-499. DOI: 10.1017/S0007114517000125. View

Lang I, Llewellyn D, Langa K, Wallace R, Melzer D . Neighbourhood deprivation and incident mobility disability in older adults. Age Ageing. 2008; 37(4):403-10. PMC: 2574954. DOI: 10.1093/ageing/afn092. View

Tan M, Yu J, Tan C, Wang H, Meng X, Wang C . Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis. J Alzheimers Dis. 2014; 43(2):589-603. DOI: 10.3233/JAD-140837. View

Lev-Vachnish Y, Cadury S, Rotter-Maskowitz A, Feldman N, Roichman A, Illouz T . L-Lactate Promotes Adult Hippocampal Neurogenesis. Front Neurosci. 2019; 13:403. PMC: 6542996. DOI: 10.3389/fnins.2019.00403. View

Kim H, Suzuki T, Saito K, Yoshida H, Kobayashi H, Kato H . Effects of exercise and amino acid supplementation on body composition and physical function in community-dwelling elderly Japanese sarcopenic women: a randomized controlled trial. J Am Geriatr Soc. 2011; 60(1):16-23. DOI: 10.1111/j.1532-5415.2011.03776.x. View

Gray S, Hanlon J, Landerman L, Artz M, Schmader K, Fillenbaum G . Is antioxidant use protective of cognitive function in the community-dwelling elderly?. Am J Geriatr Pharmacother. 2004; 1(1):3-10. DOI: 10.1016/s1543-5946(03)80011-9. View

Bravata D, Smith-Spangler C, Sundaram V, Gienger A, Lin N, Lewis R . Using pedometers to increase physical activity and improve health: a systematic review. JAMA. 2007; 298(19):2296-304. DOI: 10.1001/jama.298.19.2296. View

10.

Shimada H, Suzuki T, Suzukawa M, Makizako H, Doi T, Yoshida D . Performance-based assessments and demand for personal care in older Japanese people: a cross-sectional study. BMJ Open. 2013; 3(4). PMC: 3641481. DOI: 10.1136/bmjopen-2012-002424. View

11.

Ludyga S, Gerber M, Puhse U, Looser V, Kamijo K . Systematic review and meta-analysis investigating moderators of long-term effects of exercise on cognition in healthy individuals. Nat Hum Behav. 2020; 4(6):603-612. DOI: 10.1038/s41562-020-0851-8. View

12.

Nakamura M, Tazaki F, Nomura K, Takano T, Hashimoto M, Hashizume H . Cognitive impairment associated with locomotive syndrome in community-dwelling elderly women in Japan. Clin Interv Aging. 2017; 12:1451-1457. PMC: 5602419. DOI: 10.2147/CIA.S142538. View

13.

Makizako H, Shimada H, Doi T, Tsutsumimoto K, Lee S, Lee S . Age-dependent changes in physical performance and body composition in community-dwelling Japanese older adults. J Cachexia Sarcopenia Muscle. 2017; 8(4):607-614. PMC: 5566639. DOI: 10.1002/jcsm.12197. View

14.

Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges J . The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry. 2006; 21(11):1078-85. DOI: 10.1002/gps.1610. View

15.

Barnes D, Yaffe K . The projected effect of risk factor reduction on Alzheimer's disease prevalence. Lancet Neurol. 2011; 10(9):819-28. PMC: 3647614. DOI: 10.1016/S1474-4422(11)70072-2. View

16.

Janssen I, Heymsfield S, Wang Z, Ross R . Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr. J Appl Physiol (1985). 2000; 89(1):81-8. DOI: 10.1152/jappl.2000.89.1.81. View

17.

Ichinose T, Moriyasu K, Nakahata A, Tanaka M, Matsui T, Furuya S . Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain. Biosci Biotechnol Biochem. 2015; 79(9):1542-7. DOI: 10.1080/09168451.2015.1044932. View

18.

Launer L, Masaki K, Petrovitch H, Foley D, Havlik R . The association between midlife blood pressure levels and late-life cognitive function. The Honolulu-Asia Aging Study. JAMA. 1995; 274(23):1846-51. View

19.

Kim H, Kim M, Kojima N, Fujino K, Hosoi E, Kobayashi H . Exercise and Nutritional Supplementation on Community-Dwelling Elderly Japanese Women With Sarcopenic Obesity: A Randomized Controlled Trial. J Am Med Dir Assoc. 2016; 17(11):1011-1019. DOI: 10.1016/j.jamda.2016.06.016. View

20.

Spartano N, Demissie S, Himali J, Dukes K, Murabito J, Vasan R . Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study. Alzheimers Dement (N Y). 2019; 5:618-626. PMC: 6807299. DOI: 10.1016/j.trci.2019.08.007. View