Exploration of the Link Between Gut Microbiota and Purinergic Signalling

Overview

Journal Purinergic Signal

Publisher Springer

Date 2022 Sep 19

PMID 36121551

Authors

Mingjian Li

Bowen Liu

Rong Li

Ping Yang

Ping Leng

Yong Huang

Affiliations

Soon will be listed here.

Abstract

Growing evidence reveals that microorganisms in the gut are linked to metabolic health and disease risk in human beings to a considerable extent. The focus of research at this stage must tend to focus on cause-and-effect studies. In addition to being a component of DNA and RNA, purine metabolites can be involved in purine signalling in the body as chemical messengers. Abnormalities in purinergic signalling may lead to neuropathy, rheumatic immune diseases, inflammation, tumors, and a wide range of other diseases. It has proved that gut microbes are involved in purinergic signalling. The relationship between these gut-derived purinergic signalling molecules and host metabolism may be one of the important clues to our understanding of the mechanisms by which the microbiota affects host metabolism.

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