International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and Three Virtual Business Meetings: Update on Blood Group Systems

Overview

Journal Vox Sang

Specialty Hematology

Date 2022 Sep 19

PMID 36121188

Authors

Christoph Gassner

Lilian Castilho

Qing Chen

Frederik Banch Clausen

Gregory A Denomme

Willy A Flegel

Nick Gleadall

Asa Hellberg

Yanli Ji

Margaret A Keller

William J Lane

Peter Ligthart

Christine Lomas-Francis

Nuria Nogues

Martin L Olsson

Thierry Peyrard

Jill R Storry

Yoshihiko Tani

Nicole Thornton

Ellen van der Schoot

Barbera Veldhuisen

Franz Wagner

Christof Weinstock

Silvano Wendel

Connie Westhoff

Vered Yahalom

Catherine A Hyland

Affiliations

Soon will be listed here.

Abstract

Background And Objectives: Under the ISBT, the Working Party (WP) for Red Cell Immunogenetics and Blood Group Terminology is charged with ratifying blood group systems, antigens and alleles. This report presents the outcomes from four WP business meetings, one located in Basel in 2019 and three held as virtual meetings during the COVID-19 pandemic in 2020 and 2021.

Materials And Methods: As in previous meetings, matters pertaining to blood group antigen nomenclature were discussed. New blood group systems and antigens were approved and named according to the serologic, genetic, biochemical and cell biological evidence presented.

Results: Seven new blood group systems, KANNO (defined numerically as ISBT 037), SID (038), CTL2 (039), PEL (040), MAM (041), EMM (042) and ABCC1 (043) were ratified. Two (039 and 043) were de novo discoveries, and the remainder comprised reported antigens where the causal genes were previously unknown. A further 15 blood group antigens were added to the existing blood group systems: MNS (002), RH (004), LU (005), DI (010), SC (013), GE (020), KN (022), JMH (026) and RHAG (030).

Conclusion: The ISBT now recognizes 378 antigens, of which 345 are clustered within 43 blood group systems while 33 still have an unknown genetic basis. The ongoing discovery of new blood group systems and antigens underscores the diverse and complex biology of the red cell membrane. The WP continues to update the blood group antigen tables and the allele nomenclature tables. These can be found on the ISBT website (http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/).

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