Redundant Mechanisms Regulating the Proliferation Vs. Differentiation Balance in the Germline

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2022 Sep 19

PMID 36120589

Authors

Kara Vanden Broek

Xue Han

Dave Hansen

Affiliations

Soon will be listed here.

Abstract

The proper production of gametes over an extended portion of the life of an organism is essential for a high level of fitness. The balance between germline stem cell (GSC) proliferation (self-renewal) and differentiation (production of gametes) must be tightly regulated to ensure proper gamete production and overall fitness. Therefore, organisms have evolved robust regulatory systems to control this balance. Here we discuss the redundancy in the regulatory system that controls the proliferation vs. differentiation balance in the hermaphrodite germline, and how this redundancy may contribute to robustness. We focus on the various types of redundancy utilized to regulate this balance, as well as the approaches that have enabled these redundant mechanisms to be uncovered.

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