Neuregulin-1, a Potential Therapeutic Target for Cardiac Repair

Overview

Journal Front Pharmacol

Date 2022 Sep 19

PMID 36120374

Authors

Yan Wang

Jianliang Wei

Peng Zhang

Xin Zhang

Yifei Wang

Wenjing Chen

Yanan Zhao

Xiangning Cui

Affiliations

Soon will be listed here.

Abstract

NRG1 (Neuregulin-1) is an effective cardiomyocyte proliferator, secreted and released by endothelial vascular cells, and affects the cardiovascular system. It plays a major role in heart growth, proliferation, differentiation, apoptosis, and other cardiovascular processes. Numerous experiments have shown that NRG1 can repair the heart in the pathophysiology of atherosclerosis, myocardial infarction, ischemia reperfusion, heart failure, cardiomyopathy and other cardiovascular diseases. NRG1 can connect related signaling pathways through the NRG1/ErbB pathway, which form signal cascades to improve the myocardial microenvironment, such as regulating cardiac inflammation, oxidative stress, necrotic apoptosis. Here, we summarize recent research advances on the molecular mechanisms of NRG1, elucidate the contribution of NRG1 to cardiovascular disease, discuss therapeutic approaches targeting NRG1 associated with cardiovascular disease, and highlight areas for future research.

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