The Potential Roles of Interleukin-25 in Infectious Diseases

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Sep 19

PMID 36119076

Authors

Jing Wu

Fang Zhang

Hongji Tao

Waqas Nawaz

Deyan Chen

Zhiwei Wu

Affiliations

Soon will be listed here.

Abstract

Interleukin-25 (IL-25), also known as IL-17E, is a recently identified cytokine of the IL-17 family. Numerous studies illustrated that the expression of IL-25 is regulated by multiple pathogens, including parasitic, viral, and bacterial infections. IL-25 has a dual function in infectious diseases. On the one hand, IL-25 activates type 2 immunity the relevant cytokines, including IL-4, IL-5, and IL-13, which are associated with the development of pathogenic infection-related allergic diseases. On the other hand, IL-25 involves in the recruitment of group 2 innate lymphoid cells (ILC2) to enhanced T helper 2 (Th2) cell differentiation, which are important to the clearance of pathogens. However, the precise roles of IL-25 in infectious diseases remain largely unknown. Thus, the current review will shed light on the pivotal roles of IL-25 in infectious diseases.

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References

Xie S, Dick L, Gould A, Brand S, Tilley L . The proteasome as a target for protozoan parasites. Expert Opin Ther Targets. 2019; 23(11):903-914. DOI: 10.1080/14728222.2019.1685981. View

Su J, Chen T, Ji X, Liu C, Yadav P, Wu R . IL-25 downregulates Th1/Th17 immune response in an IL-10-dependent manner in inflammatory bowel disease. Inflamm Bowel Dis. 2013; 19(4):720-8. DOI: 10.1097/MIB.0b013e3182802a76. View

Unno H, Arae K, Matsuda A, Ikutani M, Tamari M, Motomura K . Critical role of IL-33, but not IL-25 or TSLP, in silica crystal-mediated exacerbation of allergic airway eosinophilia. Biochem Biophys Res Commun. 2020; 533(3):493-500. DOI: 10.1016/j.bbrc.2020.09.046. View

Owyang A, Zaph C, Wilson E, Guild K, Mcclanahan T, Miller H . Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med. 2006; 203(4):843-9. PMC: 1800834. DOI: 10.1084/jem.20051496. View

Ikeda K, Nakajima H, Suzuki K, Kagami S, Hirose K, Suto A . Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation. Blood. 2003; 101(9):3594-6. DOI: 10.1182/blood-2002-09-2817. View

Yasuda Y, Nagano T, Kobayashi K, Nishimura Y . Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model. Cells. 2020; 9(5). PMC: 7290734. DOI: 10.3390/cells9051178. View

Yi L, Cheng D, Zhang K, Huo X, Mo Y, Shi H . Intelectin contributes to allergen-induced IL-25, IL-33, and TSLP expression and type 2 response in asthma and atopic dermatitis. Mucosal Immunol. 2017; 10(6):1491-1503. PMC: 5568519. DOI: 10.1038/mi.2017.10. View

Damour A, Garcia M, Seneschal J, Leveque N, Bodet C . Eczema Herpeticum: Clinical and Pathophysiological Aspects. Clin Rev Allergy Immunol. 2019; 59(1):1-18. DOI: 10.1007/s12016-019-08768-3. View

de Oliveira Nobrega C, do Nascimento W, Santos P, Lorena V, Medeiros D, Costa V . Schistosoma mansoni infection is associated with decreased risk of respiratory allergy symptoms and low production of CCL2. Trop Med Int Health. 2021; 26(9):1098-1109. DOI: 10.1111/tmi.13639. View

10.

Galli G, Saleh M . Immunometabolism of Macrophages in Bacterial Infections. Front Cell Infect Microbiol. 2021; 10:607650. PMC: 7879570. DOI: 10.3389/fcimb.2020.607650. View

11.

Ong P . New insights in the pathogenesis of atopic dermatitis. Pediatr Res. 2013; 75(1-2):171-5. DOI: 10.1038/pr.2013.196. View

12.

Celebi Sozener Z, Cevhertas L, Nadeau K, Akdis M, Akdis C . Environmental factors in epithelial barrier dysfunction. J Allergy Clin Immunol. 2020; 145(6):1517-1528. DOI: 10.1016/j.jaci.2020.04.024. View

13.

Feng J, Li L, Ou Z, Li Q, Gong B, Zhao Z . IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity. Cell Mol Immunol. 2017; 15(5):493-505. PMC: 6068125. DOI: 10.1038/cmi.2016.71. View

14.

Zaiss M, Maslowski K, Mosconi I, Guenat N, Marsland B, Harris N . IL-1β suppresses innate IL-25 and IL-33 production and maintains helminth chronicity. PLoS Pathog. 2013; 9(8):e1003531. PMC: 3731249. DOI: 10.1371/journal.ppat.1003531. View

15.

Tsai M, Tsai Y, Lin Y, Hsu Y, Chen Y, Tsai M . IL-25 Induced ROS-Mediated M2 Macrophage Polarization via AMPK-Associated Mitophagy. Int J Mol Sci. 2022; 23(1). PMC: 8744791. DOI: 10.3390/ijms23010003. View

16.

Gerbe F, Sidot E, Smyth D, Ohmoto M, Matsumoto I, Dardalhon V . Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature. 2016; 529(7585):226-30. PMC: 7614903. DOI: 10.1038/nature16527. View

17.

Roger S, Ducancelle A, Le Guillou-Guillemette H, Gaudy C, Lunel F . HCV virology and diagnosis. Clin Res Hepatol Gastroenterol. 2021; 45(3):101626. DOI: 10.1016/j.clinre.2021.101626. View

18.

Buonomo E, Cowardin C, Wilson M, Saleh M, Pramoonjago P, Petri Jr W . Microbiota-Regulated IL-25 Increases Eosinophil Number to Provide Protection during Clostridium difficile Infection. Cell Rep. 2016; 16(2):432-443. PMC: 4945404. DOI: 10.1016/j.celrep.2016.06.007. View

19.

Salimi M, Barlow J, Saunders S, Xue L, Gutowska-Owsiak D, Wang X . A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med. 2013; 210(13):2939-50. PMC: 3865470. DOI: 10.1084/jem.20130351. View

20.

Nam H, Ison M . Respiratory syncytial virus infection in adults. BMJ. 2019; 366:l5021. DOI: 10.1136/bmj.l5021. View