Based on Molecular Structures: Amyloid-β Generation, Clearance, Toxicity and Therapeutic Strategies

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2022 Sep 19

PMID 36117918

Authors

Hai Yang

Jinping Li

Xiaoxiong Li

Linqiu Ma

Mingliang Hou

Huadong Zhou

Rui Zhou

Affiliations

Soon will be listed here.

Abstract

Amyloid-β (Aβ) has long been considered as one of the most important pathogenic factors in Alzheimer's disease (AD), but the specific pathogenic mechanism of Aβ is still not completely understood. In recent years, the development of structural biology technology has led to new understandings about Aβ molecular structures, Aβ generation and clearance from the brain and peripheral tissues, and its pathological toxicity. The purpose of the review is to discuss Aβ metabolism and toxicity, and the therapeutic strategy of AD based on the latest progress in molecular structures of Aβ. The Aβ structure at the atomic level has been analyzed, which provides a new and refined perspective to comprehend the role of Aβ in AD and to formulate therapeutic strategies of AD.

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