Soy Product Consumption and the Risk of Major Depressive Disorder in Older Adults: Evidence from a Cohort Study

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2022 Sep 19

PMID 36117647

Authors

Tao Zhang

Guojun Jiang

Fudong Li

Xue Gu

Yujia Zhai

Le Xu

Mengna Wu

Hongwei Shen

Junfen Lin

Affiliations

Soon will be listed here.

Abstract

Background: To explore the association between soy product consumption and the risk of depression in the community.

Methods: In 2014, a total of 10,901 older people were recruited from Zhejiang province, China, and completed food frequency interviews. Participants were followed up over the next 6 years, and depression was assessed at each visit. Finally, 6,253 participants were included in the present study. Mixed effects models were performed to analyze the association by multivariate adjustments for potential confounders.

Results: Over four-fifths of the eligible participants took soy food at least one day per week. The mixed effects model has shown the adjusted odds ratios (95% CI) of high-frequency consumers (4-7 days per week) were 0.46 (0.39-0.54) for depression with a cut-off score of 5, compared with non-consumers.

Conclusions: More frequent soy product consumption was associated with a lower risk of depression.

Citing Articles

Associations of physical activity and soybean product consumption with psychological symptoms: a cross-sectional survey of Chinese university students.

Qiu Q, Chai G, Xu M, Xiao J BMC Sports Sci Med Rehabil. 2024; 16(1):162.

PMID: 39061095 PMC: 11282836. DOI: 10.1186/s13102-024-00952-z.

Association between ambient fine particular matter components and subsequent cognitive impairment in community-dwelling older people: a prospective cohort study from eastern China.

Zhang T, Liu W, Yang T, Zhai Y, Gu X, Xu L Aging Clin Exp Res. 2024; 36(1):150.

PMID: 39060791 PMC: 11282123. DOI: 10.1007/s40520-024-02793-9.

Nutrition and Healthy Ageing in Asia: A Systematic Review.

Zhou Y, Song X, Pan A, Koh W Nutrients. 2023; 15(14).

PMID: 37513571 PMC: 10383719. DOI: 10.3390/nu15143153.

Recent advances in exploring and exploiting soybean functional peptides-a review.

Zhu Y, Chen G, Diao J, Wang C Front Nutr. 2023; 10:1185047.

PMID: 37396130 PMC: 10310054. DOI: 10.3389/fnut.2023.1185047.

References

Levis B, Benedetti A, Thombs B . Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis. BMJ. 2019; 365:l1476. PMC: 6454318. DOI: 10.1136/bmj.l1476. View

Tsai A, Lucas M, Okereke O, OReilly E, Mirzaei F, Kawachi I . Suicide mortality in relation to dietary intake of n-3 and n-6 polyunsaturated fatty acids and fish: equivocal findings from 3 large US cohort studies. Am J Epidemiol. 2014; 179(12):1458-66. PMC: 4051877. DOI: 10.1093/aje/kwu086. View

Sugawara N, Yasui-Furukori N, Tsuchimine S, Kaneda A, Tsuruga K, Iwane K . No association between dietary patterns and depressive symptoms among a community-dwelling population in Japan. Ann Gen Psychiatry. 2012; 11(1):24. PMC: 3532227. DOI: 10.1186/1744-859X-11-24. View

Nanri A, Eguchi M, Kuwahara K, Kochi T, Kurotani K, Ito R . Macronutrient intake and depressive symptoms among Japanese male workers: the Furukawa Nutrition and Health Study. Psychiatry Res. 2014; 220(1-2):263-8. DOI: 10.1016/j.psychres.2014.08.026. View

Nanri A, Kimura Y, Matsushita Y, Ohta M, Sato M, Mishima N . Dietary patterns and depressive symptoms among Japanese men and women. Eur J Clin Nutr. 2010; 64(8):832-9. DOI: 10.1038/ejcn.2010.86. View

Miki T, Eguchi M, Akter S, Kochi T, Kuwahara K, Kashino I . Longitudinal adherence to a dietary pattern and risk of depressive symptoms: the Furukawa Nutrition and Health Study. Nutrition. 2018; 48:48-54. DOI: 10.1016/j.nut.2017.10.023. View

Atteritano M, Mazzaferro S, Bitto A, Cannata M, DAnna R, Squadrito F . Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: a 2-year randomized, double-blind, controlled study. Osteoporos Int. 2013; 25(3):1123-9. DOI: 10.1007/s00198-013-2512-5. View

Park S, Kim M, Lee H . The association between dietary pattern and depression in middle-aged Korean adults. Nutr Res Pract. 2019; 13(4):316-322. PMC: 6669070. DOI: 10.4162/nrp.2019.13.4.316. View

Ocklenburg S, Borawski J . Vegetarian diet and depression scores: A meta-analysis. J Affect Disord. 2021; 294:813-815. DOI: 10.1016/j.jad.2021.07.098. View

10.

Wang W, Bian Q, Zhao Y, Li X, Wang W, Du J . Reliability and validity of the Chinese version of the Patient Health Questionnaire (PHQ-9) in the general population. Gen Hosp Psychiatry. 2014; 36(5):539-44. DOI: 10.1016/j.genhosppsych.2014.05.021. View

11.

Qiu Y, Ren W, Liu Y, Yin P, Ren J . Online health information in a rural residential population in Zhejiang Province, China: a cross-sectional study. BMJ Open. 2019; 9(5):e026202. PMC: 6502021. DOI: 10.1136/bmjopen-2018-026202. View

12.

Tsai A, Chang T, Chi S . Frequent consumption of vegetables predicts lower risk of depression in older Taiwanese - results of a prospective population-based study. Public Health Nutr. 2011; 15(6):1087-92. DOI: 10.1017/S1368980011002977. View

13.

Wang L, Wu X, Ma Y, Li X, Zhang J, Zhao L . Supplementation with soy isoflavones alleviates depression-like behaviour reshaping the gut microbiota structure. Food Funct. 2021; 12(11):4995-5006. DOI: 10.1039/d0fo03254a. View

14.

Li F, Liu X, Zhang D . Fish consumption and risk of depression: a meta-analysis. J Epidemiol Community Health. 2015; 70(3):299-304. DOI: 10.1136/jech-2015-206278. View

15.

Hirose A, Terauchi M, Akiyoshi M, Owa Y, Kato K, Kubota T . Low-dose isoflavone aglycone alleviates psychological symptoms of menopause in Japanese women: a randomized, double-blind, placebo-controlled study. Arch Gynecol Obstet. 2015; 293(3):609-15. PMC: 4757620. DOI: 10.1007/s00404-015-3849-0. View

16.

Roy T, Lloyd C . Epidemiology of depression and diabetes: a systematic review. J Affect Disord. 2012; 142 Suppl:S8-21. DOI: 10.1016/S0165-0327(12)70004-6. View

17.

Ho C, Feng L, Fam J, Mahendran R, Kua E, Ng T . Coexisting medical comorbidity and depression: multiplicative effects on health outcomes in older adults. Int Psychogeriatr. 2014; 26(7):1221-9. DOI: 10.1017/S1041610214000611. View

18.

Lu C, Gao R, Zhang Y, Jiang N, Chen Y, Sun J . S-equol, a metabolite of dietary soy isoflavones, alleviates lipopolysaccharide-induced depressive-like behavior in mice by inhibiting neuroinflammation and enhancing synaptic plasticity. Food Funct. 2021; 12(13):5770-5778. DOI: 10.1039/d1fo00547b. View

19.

Choi K, Stein M, Nishimi K, Ge T, Coleman J, Chen C . An Exposure-Wide and Mendelian Randomization Approach to Identifying Modifiable Factors for the Prevention of Depression. Am J Psychiatry. 2020; 177(10):944-954. PMC: 9361193. DOI: 10.1176/appi.ajp.2020.19111158. View

20.

Garcia-Pena C, Wagner F, Sanchez-Garcia S, Espinel-Bermudez C, Juarez-Cedillo T, Perez-Zepeda M . Late-life depressive symptoms: prediction models of change. J Affect Disord. 2013; 150(3):886-94. PMC: 3759587. DOI: 10.1016/j.jad.2013.05.007. View