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Periconceptional Folic Acid Supplementation and Child Asthma: a Follow-up Study

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Abstract

Objective: High maternal folic acid exposure has been studied as a risk factor for child asthma with inconclusive results. Folic acid supplementation that begins before pregnancy may propagate high exposures during pregnancy, particularly in regions with fortified food supplies. We investigated whether folic acid supplementation initiated periconceptionally is associated with childhood asthma in a US cohort.

Materials And Methods: We re-contacted mother-child dyads previously enrolled in a prospective pregnancy cohort and included children age 4 to 8 years at follow-up ( = 540). Using first trimester interviews, we assessed whether initial folic acid-containing supplement (FACS) use occurred near/before estimated conception ("periconceptional") or after (during the "first trimester"). Follow-up questionnaires were used to determine if a child ever had an asthma diagnosis ("ever asthma") or asthma diagnosis with prevalent symptoms or medication use ("current asthma"). We examined associations between FACS initiation and asthma outcomes using logistic regression, excluding preterm births and adjusting for child age, sex, maternal race, maternal education, and parental asthma.

Results: Approximately half of women initiated FACS use periconceptionally (49%). Nine percent of children had "ever asthma" and 6% had "current asthma." Periconceptional initiation was associated with elevated odds of ever asthma [adjusted odds ratio (95% Confidence Interval): 1.65 (0.87, 3.14)] and current asthma [1.87 (0.88, 4.01)], relative to first trimester initiation.

Conclusion: We observed positive, but imprecisely estimated associations between periconceptional FACS initiation and child asthma. Folic acid prevents birth defects and is recommended. However, larger studies of folic acid dosing and timing, with consideration for childhood asthma, are needed.

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References
1.
Tinker S, Hamner H, Qi Y, Crider K . U.S. women of childbearing age who are at possible increased risk of a neural tube defect-affected pregnancy due to suboptimal red blood cell folate concentrations, National Health and Nutrition Examination Survey 2007 to 2012. Birth Defects Res A Clin Mol Teratol. 2015; 103(6):517-26. PMC: 4515959. DOI: 10.1002/bdra.23378. View

2.
Magdelijns F, Mommers M, Penders J, Smits L, Thijs C . Folic acid use in pregnancy and the development of atopy, asthma, and lung function in childhood. Pediatrics. 2011; 128(1):e135-44. DOI: 10.1542/peds.2010-1690. View

3.
Bailey R, Dodd K, Gahche J, Dwyer J, McDowell M, Yetley E . Total folate and folic acid intake from foods and dietary supplements in the United States: 2003-2006. Am J Clin Nutr. 2009; 91(1):231-7. PMC: 2793110. DOI: 10.3945/ajcn.2009.28427. View

4.
Martinussen M, Risnes K, Jacobsen G, Bracken M . Folic acid supplementation in early pregnancy and asthma in children aged 6 years. Am J Obstet Gynecol. 2011; 206(1):72.e1-7. PMC: 3246127. DOI: 10.1016/j.ajog.2011.07.033. View

5.
. Vital signs: asthma prevalence, disease characteristics, and self-management education: United States, 2001--2009. MMWR Morb Mortal Wkly Rep. 2011; 60(17):547-52. View