BCAT1 Promotes Lung Adenocarcinoma Progression Through Enhanced Mitochondrial Function and NF-κB Pathway Activation

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2022 Sep 16

PMID 36111572

Authors

Mengdan Yu

Qianwei Zhao

Jinxia Li

Fang Xu

Zhibiao Zhang

Yixian Liu

Liping Dai

Bingxia Zhang

Jianying Zhang

Jintao Zhang

Affiliations

Soon will be listed here.

Abstract

Lung cancer is one of the most prevalent and malignant cancers, among which lung adenocarcinoma (LUAD) accounts for the majority and remains a major cause of cancer-related mortality worldwide (Cui et al., 2019). Despite the growing intensity of research on the pathobiology and progression of lung cancer and the fact that many genes have been identified as potential drivers and targets for therapy (Luo et al., 2019; Zhang et al., 2019), the treatment and prognosis of lung cancer patients have hardly improved. Therefore, this study aimed to investigate the precise mechanism of lung cancer development and explore efficient diagnostic and therapeutic methods for clinical treatment.

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