Functional Cure of a Chronic Virus Infection by Shifting the Virus - Host Equilibrium State

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Sep 16

PMID 36110838

Authors

Gennady Bocharov

Dmitry Grebennikov

Paula Cebollada Rica

Eva Domenjo-Vila

Valentina Casella

Andreas Meyerhans

Affiliations

Soon will be listed here.

Abstract

The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and the prediction of multiplicative cooperativity between virus-specific cytotoxic T cells and neutralising antibodies, we argue for the requirements to engage multiple immune system components for functional cure strategies. Our arguments are derived from LCMV model system studies and are translated to HIV-1 infection.

Citing Articles

Stochastic Modelling of HIV-1 Replication in a CD4 T Cell with an IFN Response.

Sazonov I, Grebennikov D, Savinkov R, Soboleva A, Pavlishin K, Meyerhans A Viruses. 2023; 15(2).

PMID: 36851511 PMC: 9966781. DOI: 10.3390/v15020296.

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