A Review of Humoral and Cellular Immune Responses to SARS-CoV-2 Vaccination Following Solid Organ Transplantation

Overview

Journal Ann Transplant

Specialty General Surgery

Date 2022 Sep 16

PMID 36110033

Authors

Ilona Cieslak

Magdalena Kwapisz

Olga Tronina

Joanna Gotlib

Wojciech Lisik

Dariusz Wasiak

Marta Hrenczuk

Mansur Rahnama

Piotr Malkowski

Affiliations

Soon will be listed here.

Abstract

The introduction of vaccines preventing a severe course of COVID-19 disease is particularly important in immunocompromised patients, among whom organ recipients and patients awaiting transplantation constitute a large group. The article is a critical review of 68 recent publications on the impact of the SARS-CoV-2 pandemic on transplantology worldwide. The study discusses research results concerning various aspects of SARS-CoV-2 vaccination in transplant patients; it also lists important factors influencing vaccination effectiveness. A suboptimal immune response to 2 doses of vaccine in this group of patients is a major challenge prompting further research. Therefore, this review aims to provide an update on the humoral and cellular immune responses to SARS-CoV-2 vaccination following solid organ transplantation.

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