The Morphogenesis of the Human Paneth Cell. An Immunocytochemical Ultrastructural Study

Overview

Journal Histochemistry

Specialty Biochemistry

Date 1987 Jan 1

PMID 3610676

Citations 9

Authors

M Mathan

J Hughes

R Whitehead

Affiliations

Soon will be listed here.

Abstract

In human duodenal mucosa Paneth cells originate away from the base of crypts and migrate towards the base during maturation. The earliest cells in the Paneth cell lineage could be identified by labelling of lysozyme in the Golgi apparatus. Specific labelling for lysozyme was present in the rough endoplasmic reticulum, Golgi apparatus, condensing vacuoles, granules and many lysosomes of mature Paneth cells. The maturation of the Paneth cell is accompanied by an increase in the content of lysozyme in the secretory granules and with senescence lysozyme diffuses into the cytoplasm.

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References

Mathan M, MATHAN V . Rectal mucosal morphologic abnormalities in normal subjects in southern India: a tropical colonopathy?. Gut. 1985; 26(7):710-7. PMC: 1433018. DOI: 10.1136/gut.26.7.710. View

Montero C, Erlandsen S . Immunocytochemical and histochemical studies on intestinal epithelial cells producing both lysozyme and mucosubstance. Anat Rec. 1978; 190(1):127-41. DOI: 10.1002/ar.1091900111. View

Erlandsen S . Cytodifferentiation of the rat Paneth cell: an immunocytochemical investigation in suckling and weanling animals. Am J Anat. 1980; 158(3):285-97. DOI: 10.1002/aja.1001580305. View

Creamer B . Paneth-cell function. Lancet. 1967; 1(7485):314-6. DOI: 10.1016/s0140-6736(67)91245-7. View

Elmes M, Stanton M, Howells C, LOWE G . Relation between the mucosal flora and Paneth cell population of human jejunum and ileum. J Clin Pathol. 1984; 37(11):1268-71. PMC: 498996. DOI: 10.1136/jcp.37.11.1268. View

Rodning C, Wilson I, Erlandsen S . Immunoglobulins within human small-intestinal Paneth cells. Lancet. 1976; 1(7967):984-7. DOI: 10.1016/s0140-6736(76)91860-2. View

Bosman F . Some recent developments in immunocytochemistry. Histochem J. 1983; 15(3):189-200. DOI: 10.1007/BF01006235. View

Cheng H, Leblond C . Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anat. 1974; 141(4):537-61. DOI: 10.1002/aja.1001410407. View

Erlandsen S, Parsons J, Taylor T . Ultrastructural immunocytochemical localization of lysozyme in the Paneth cells of man. J Histochem Cytochem. 1974; 22(6):401-13. DOI: 10.1177/22.6.401. View

10.

Cheng H . Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cells. Am J Anat. 1974; 141(4):521-35. DOI: 10.1002/aja.1001410406. View

11.

SPICER S, Frayser R, Virella G, Hall B . Immunocytochemical localization of lysozymes in respiratory and other tissues. Lab Invest. 1977; 36(3):282-95. View

12.

Sandow M, Whitehead R . The Paneth cell. Gut. 1979; 20(5):420-31. PMC: 1412432. DOI: 10.1136/gut.20.5.420. View

13.

Bjerknes M, Cheng H . The stem-cell zone of the small intestinal epithelium. I. Evidence from Paneth cells in the adult mouse. Am J Anat. 1981; 160(1):51-63. DOI: 10.1002/aja.1001600105. View

14.

GRUBE D . Immunoreactivities of gastrin (G-) cells. II. Non-specific binding of immunoglobulins to G-cells by ionic interactions. Histochemistry. 1980; 66(2):149-67. DOI: 10.1007/BF00494642. View

15.

Subbuswamy S . Paneth cells and goblet cells. J Pathol. 1973; 111(3):181-9. DOI: 10.1002/path.1711110306. View