Advances in the Study of HLA Class Ib in Maternal-fetal Immune Tolerance

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Sep 15

PMID 36105800

Authors

Yiran Yang

Wanning Wang

Jing Weng

Huifang Li

Yanmin Ma

Lingyan Liu

Wei Ma

Affiliations

Soon will be listed here.

Abstract

The HLA class Ib molecule is an alloantigen that causes transplant rejection on behalf of individual human and plays an important role in maternal-fetal immune tolerance. Early studies on HLA class Ib focused on the mechanism of HLA-G-induced immune escape, but in recent years, studies on the mechanism of HLA-G have deepened and gradually explored the mechanism of HLA-E and HLA-F, which are also HLA class Ib molecules. In the maternal-fetal interface, trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cells by binding to inhibitory receptors of decidual immune cells (DICs) and shifting Th1/Th2 balance toward Th2 bias. Further studies on the molecular mechanism of HLA class Ib molecules provide a reference for its application in the field of clinical assisted reproduction.

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