Exosomes: A Novel Insight into Traditional Chinese Medicine

Overview

Journal Front Pharmacol

Date 2022 Sep 15

PMID 36105201

Authors

Chao Mo

Jie Zhao

Jingyan Liang

Huiling Wang

Yu Chen

Guodong Huang

Affiliations

Soon will be listed here.

Abstract

Exosomes are small extracellular vesicles and play an essential role in the mediation of intercellular communication both in health and disease. Traditional Chinese medicine (TCM) has historically been used to maintain human health and treat various diseases up till today. The interplay between exosomes and TCM has attracted researchers' growing attention. By integrating the available evidence, TCM formulas and compounds isolated from TCM as exosome modulators have beneficial effects on multiple disorders, such as tumors, kidney diseases, and hepatic disease, which may associate with inhibiting cells proliferation, anti-inflammation, anti-oxidation, and attenuating fibrosis. Exosomes, a natural delivery system, are essential in delivering compounds isolated from TCM to target cells or tissues. Moreover, exosomes may be the potential biomarkers for TCM syndromes, providing strategies for TCM treatment. These findings may provide a novel insight into TCM from exosomes and serve as evidence for better understanding and development of TCM.

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References

Chan H, Ng T . Traditional Chinese Medicine (TCM) and Allergic Diseases. Curr Allergy Asthma Rep. 2020; 20(11):67. DOI: 10.1007/s11882-020-00959-9. View

Whyte C, Bishop E, Ruckerl D, Gaspar-Pereira S, Barker R, Allen J . Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function. J Leukoc Biol. 2011; 90(5):845-54. DOI: 10.1189/jlb.1110644. View

El Andaloussi S, Mager I, Breakefield X, Wood M . Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013; 12(5):347-57. DOI: 10.1038/nrd3978. View

Liang L, Zhao L, Wang Y, Wang Y . Treatment for Hepatocellular Carcinoma Is Enhanced When Norcantharidin Is Encapsulated in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells. Mol Pharm. 2021; 18(3):1003-1013. DOI: 10.1021/acs.molpharmaceut.0c00976. View

Zhang W, Li X, Tang Y, Chen C, Jing R, Liu T . miR-155-5p Implicates in the Pathogenesis of Renal Fibrosis via Targeting SOCS1 and SOCS6. Oxid Med Cell Longev. 2020; 2020:6263921. PMC: 7298347. DOI: 10.1155/2020/6263921. View

Chen S, Tang Y, Gao Y, Nie K, Wang H, Su H . Antidepressant Potential of Quercetin and its Derivatives: A Comprehensive Review and Update. Front Pharmacol. 2022; 13:865376. PMC: 9024056. DOI: 10.3389/fphar.2022.865376. View

Ostrowski M, Carmo N, Krumeich S, Fanget I, Raposo G, Savina A . Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol. 2009; 12(1):19-30. DOI: 10.1038/ncb2000. View

Cai Y, Chen J, Jiang J, Cao W, He L . Zhen-wu-tang, a blended traditional Chinese herbal medicine, ameliorates proteinuria and renal damage of streptozotocin-induced diabetic nephropathy in rats. J Ethnopharmacol. 2010; 131(1):88-94. DOI: 10.1016/j.jep.2010.06.004. View

Li Y, Su J, Sun W, Cai L, Deng Z . AMP-activated protein kinase stimulates osteoblast differentiation and mineralization through autophagy induction. Int J Mol Med. 2018; 41(5):2535-2544. PMC: 5846672. DOI: 10.3892/ijmm.2018.3498. View

10.

Wang Q, Zhou X, Zhao Y, Xiao J, Lu Y, Shi Q . Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway. Front Immunol. 2018; 9:2091. PMC: 6170622. DOI: 10.3389/fimmu.2018.02091. View

11.

Zhou J, Ren Y, Tan L, Song X, Wang M, Li Y . Norcantharidin: research advances in pharmaceutical activities and derivatives in recent years. Biomed Pharmacother. 2020; 131:110755. DOI: 10.1016/j.biopha.2020.110755. View

12.

Fang J, Zhang Y . Icariin, an Anti-atherosclerotic Drug from Chinese Medicinal Herb Horny Goat Weed. Front Pharmacol. 2017; 8:734. PMC: 5644024. DOI: 10.3389/fphar.2017.00734. View

13.

Wei Y, Li M, Cui S, Wang D, Zhang C, Zen K . Shikonin Inhibits the Proliferation of Human Breast Cancer Cells by Reducing Tumor-Derived Exosomes. Molecules. 2016; 21(6). PMC: 6274101. DOI: 10.3390/molecules21060777. View

14.

Wang Q, Hua H, Naranmandura H, Zhu H . Balance between the toxicity and anticancer activity of arsenic trioxide in treatment of acute promyelocytic leukemia. Toxicol Appl Pharmacol. 2020; 409:115299. DOI: 10.1016/j.taap.2020.115299. View

15.

Kharat M, Du Z, Zhang G, McClements D . Physical and Chemical Stability of Curcumin in Aqueous Solutions and Emulsions: Impact of pH, Temperature, and Molecular Environment. J Agric Food Chem. 2016; 65(8):1525-1532. DOI: 10.1021/acs.jafc.6b04815. View

16.

Sun Q, Gong T, Liu M, Ren S, Yang H, Zeng S . Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches. Phytomedicine. 2021; 94:153805. DOI: 10.1016/j.phymed.2021.153805. View

17.

Liu B, Lu R, Li H, Zhou Y, Zhang P, Bai L . Zhen-wu-tang ameliorates membranous nephropathy rats through inhibiting NF-κB pathway and NLRP3 inflammasome. Phytomedicine. 2019; 59:152913. DOI: 10.1016/j.phymed.2019.152913. View

18.

Chung A, Huang X, Meng X, Lan H . miR-192 mediates TGF-beta/Smad3-driven renal fibrosis. J Am Soc Nephrol. 2010; 21(8):1317-25. PMC: 2938591. DOI: 10.1681/ASN.2010020134. View

19.

Gutierrez-Millan C, Calvo Diaz C, Lanao J, Colino C . Advances in Exosomes-Based Drug Delivery Systems. Macromol Biosci. 2020; 21(1):e2000269. DOI: 10.1002/mabi.202000269. View

20.

Ji Y, Liu J, Wang Z, Li J, Li X . [Study on anti-atherosclerotic mechanisms of divided functional recipes of dahuang zhechong pill in rabbits]. Zhongguo Zhong Yao Za Zhi. 2007; 32(11):1077-81. View