The potential of Plant Extracts in Cell Therapy

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2022 Sep 14

PMID 36104798

Authors

Caifeng Li

Zhao Cui

Shiwen Deng

Peng Chen

Xianyu Li

Hongjun Yang

Affiliations

Soon will be listed here.

Abstract

Cell therapy is the frontier technology of biotechnology innovation and the most promising method for the treatment of refractory diseases such as tumours. However, cell therapy has disadvantages, such as toxicity and poor therapeutic effects. Plant extracts are natural, widely available, and contain active small molecule ingredients that are widely used in the treatment of various diseases. By studying the effect of plant extracts on cell therapy, active plant extracts that have positive significance in cell therapy can be discovered, and certain contributions to solving the current problems of attenuation and adjuvant therapy in cell therapy can be made. Therefore, this article reviews the currently reported effects of plant extracts in stem cell therapy and immune cell therapy, especially the effects of plant extracts on the proliferation and differentiation of mesenchymal stem cells and nerve stem cells and the potential role of plant extracts in chimeric antigen receptor T-cell immunotherapy (CAR-T) and T-cell receptor modified T-cell immunotherapy (TCR-T), in the hope of encouraging further research and clinical application of plant extracts in cell therapy.

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References

Li M, Chang C, Han Y, Liao C, Yu J, Wang T . Ginkgolide B promotes neuronal differentiation through the Wnt/β-catenin pathway in neural stem cells of the postnatal mammalian subventricular zone. Sci Rep. 2018; 8(1):14947. PMC: 6175824. DOI: 10.1038/s41598-018-32960-8. View

Lee J, Jung H, Han Y, Yoon Y, Yun C, Sun H . Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells. Mol Med Rep. 2016; 14(4):3777-84. PMC: 5042755. DOI: 10.3892/mmr.2016.5706. View

Wu Y, Xia L, Zhou Y, Xu Y, Jiang X . Icariin induces osteogenic differentiation of bone mesenchymal stem cells in a MAPK-dependent manner. Cell Prolif. 2015; 48(3):375-84. PMC: 6496185. DOI: 10.1111/cpr.12185. View

Wang J, Chen W, Wen C, Hung S, Chen P, Chiu J . Du-Huo-Ji-Sheng-Tang and its active component Ligusticum chuanxiong promote osteogenic differentiation and decrease the aging process of human mesenchymal stem cells. J Ethnopharmacol. 2017; 198:64-72. DOI: 10.1016/j.jep.2016.12.011. View

Wei W, Liu Y, Zhang Q, Wang Y, Zhang X, Zhang H . Danshen-Enhanced Cardioprotective Effect of Cardioplegia on Ischemia Reperfusion Injury in a Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Model. Artif Organs. 2016; 41(5):452-460. DOI: 10.1111/aor.12801. View

Yang P, Guan Y, Li Y, Zhang L, Zhang L, Li L . Icariin promotes cell proliferation and regulates gene expression in human neural stem cells in vitro. Mol Med Rep. 2016; 14(2):1316-22. DOI: 10.3892/mmr.2016.5377. View

Dai Z, Li Y, Quarles L, Song T, Pan W, Zhou H . Resveratrol enhances proliferation and osteoblastic differentiation in human mesenchymal stem cells via ER-dependent ERK1/2 activation. Phytomedicine. 2007; 14(12):806-14. DOI: 10.1016/j.phymed.2007.04.003. View

Liu J, Wang Y, Qiu Z, Lv G, Huang X, Lin H . Impact of TCM on Tumor-Infiltrating Myeloid Precursors in the Tumor Microenvironment. Front Cell Dev Biol. 2021; 9:635122. PMC: 7969811. DOI: 10.3389/fcell.2021.635122. View

Zhao H, Li Y, Wang Y, Zhang J, Ouyang X, Peng R . Antitumor and immunostimulatory activity of a polysaccharide-protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice. Food Chem Toxicol. 2012; 50(8):2648-55. DOI: 10.1016/j.fct.2012.05.018. View

10.

Saleh M, Rashedi I, Keating A . Immunomodulatory Properties of : The Role of Polysaccharopeptide. Front Immunol. 2017; 8:1087. PMC: 5592279. DOI: 10.3389/fimmu.2017.01087. View

11.

Zhuang P, Cui G, Zhang Y, Zhang M, Guo H, Zhang J . Baicalin regulates neuronal fate decision in neural stem/progenitor cells and stimulates hippocampal neurogenesis in adult rats. CNS Neurosci Ther. 2013; 19(3):154-62. PMC: 6493621. DOI: 10.1111/cns.12050. View

12.

Kim A, Lee S, Seo C, Chung S . Ethanol extract of Magnoliae cortex (EEMC) limits teratoma formation of pluripotent stem cells by selective elimination of undifferentiated cells through the p53-dependent mitochondrial apoptotic pathway. Phytomedicine. 2020; 69:153198. DOI: 10.1016/j.phymed.2020.153198. View

13.

Si Y, Li Q, Xie C, Niu X, Xia X, Yu C . Chinese herbs and their active ingredients for activating xue (blood) promote the proliferation and differentiation of neural stem cells and mesenchymal stem cells. Chin Med. 2014; 9(1):13. PMC: 3991899. DOI: 10.1186/1749-8546-9-13. View

14.

Depil S, Duchateau P, Grupp S, Mufti G, Poirot L . 'Off-the-shelf' allogeneic CAR T cells: development and challenges. Nat Rev Drug Discov. 2020; 19(3):185-199. DOI: 10.1038/s41573-019-0051-2. View

15.

Lu Q, Zhu H, Liu X, Tang C . Icariin sustains the proliferation and differentiation of Aβ-treated hippocampal neural stem cells via the BDNF-TrkB-ERK/Akt signaling pathway. Neurol Res. 2020; 42(11):936-945. DOI: 10.1080/01616412.2020.1792701. View

16.

Facklam A, Volpatti L, Anderson D . Biomaterials for Personalized Cell Therapy. Adv Mater. 2019; 32(13):e1902005. DOI: 10.1002/adma.201902005. View

17.

Qin W, Chen S, Yang S, Xu Q, Xu C, Cai J . The Effect of Traditional Chinese Medicine on Neural Stem Cell Proliferation and Differentiation. Aging Dis. 2018; 8(6):792-811. PMC: 5758352. DOI: 10.14336/AD.2017.0428. View

18.

Xu D, Xu L, Zhou C, Lee W, Wu T, Cui L . Salvianolic acid B promotes osteogenesis of human mesenchymal stem cells through activating ERK signaling pathway. Int J Biochem Cell Biol. 2014; 51:1-9. DOI: 10.1016/j.biocel.2014.03.005. View

19.

Warrier S, Haridas N, Balasubramanian S, Jalisatgi A, Bhonde R, Dharmarajan A . A synthetic formulation, Dhanwantharam kashaya, delays senescence in stem cells. Cell Prolif. 2013; 46(3):283-90. PMC: 6495558. DOI: 10.1111/cpr.12026. View

20.

Zhuang P, Zhang Y, Cui G, Bian Y, Zhang M, Zhang J . Direct stimulation of adult neural stem/progenitor cells in vitro and neurogenesis in vivo by salvianolic acid B. PLoS One. 2012; 7(4):e35636. PMC: 3335811. DOI: 10.1371/journal.pone.0035636. View