Functions of Exogenous FGF Signals in Regulation of Fibroblast to Myofibroblast Differentiation and Extracellular Matrix Protein Expression

Overview

Journal Open Biol

Specialties Biology
Cell Biology
Molecular Biology

Date 2022 Sep 14

PMID 36102060

Authors

Changye Sun

Xiangqin Tian

Yangyang Jia

Mingming Yang

Yong Li

David G Fernig

Affiliations

Soon will be listed here.

Abstract

Fibroblasts are widely distributed cells found in most tissues and upon tissue injury, they are able to differentiate into myofibroblasts, which express abundant extracellular matrix (ECM) proteins. Overexpression and unordered organization of ECM proteins cause tissue fibrosis in damaged tissue. Fibroblast growth factor (FGF) family proteins are well known to promote angiogenesis and tissue repair, but their activities in fibroblast differentiation and fibrosis have not been systematically reviewed. Here we summarize the effects of FGFs in fibroblast to myofibroblast differentiation and ECM protein expression and discuss the underlying potential regulatory mechanisms, to provide a basis for the clinical application of recombinant FGF protein drugs in treatment of tissue damage.

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