Curcumin Nanoparticles: the Topical Antimycotic Suspension Treating Oral Candidiasis

Overview

Journal Odontology

Specialty Dentistry

Date 2022 Sep 13

PMID 36100802

Authors

Souzy Kamal Anwar

Sarah Nasser Abd Elmonaem

Eglal Moussa

Aliaa Gamaleldin Aboulela

Marwa Morsy Essawy

Affiliations

Soon will be listed here.

Abstract

Phytotherapeutics is widely used nowadays as an alternative to the current antifungal drugs to reduce their side effects. Curcumin, with its wide therapeutic array as antioxidant and anti-inflammatory agent, is one of the natural compounds that ha..s an antifungal effect, especially when being used at nanoscale to increase its bioavailability. Our research aimed to evaluate clinically and microbiologically the effect of using topical nanocurcumin suspension to treat oral candidiasis. After 4 days from induction of oral candidiasis (baseline), we randomly divided 39 female BALB/c mice into three groups of 13 animals; nanocurcumin, nystatin, and sham groups. All animals in nanocurcumin and nystatin groups received topical treatment twice daily for 10 days. Then, we performed clinical and microbiological evaluations at baseline, day 5, and day 10. By the end of treatment, our results revealed that nanocurcumin promoted a significant reduction in the number of candida colonies. There was no statistically significant difference neither clinically nor microbiologically between nanocurcumin and nystatin groups. In conclusion, nanocurcumin has a good antifungal effect as nystatin, however, its therapeutic efficacy takes a longer time to appear than nystatin. The enhanced bioavailability of curcumin at the nanoscale qualifies this nano-herb as a promising alternative therapy for oral candidiasis, evading nystatin-associated morbidity.

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References

Dovigo L, Carmello J, de Souza Costa C, Vergani C, Brunetti I, Bagnato V . Curcumin-mediated photodynamic inactivation of Candida albicans in a murine model of oral candidiasis. Med Mycol. 2012; 51(3):243-51. DOI: 10.3109/13693786.2012.714081. View

Pierce C, Lopez-Ribot J . Candidiasis drug discovery and development: new approaches targeting virulence for discovering and identifying new drugs. Expert Opin Drug Discov. 2013; 8(9):1117-26. PMC: 3984500. DOI: 10.1517/17460441.2013.807245. View

Sakima V, Barbugli P, Cerri P, Chorilli M, Carmello J, Pavarina A . Antimicrobial Photodynamic Therapy Mediated by Curcumin-Loaded Polymeric Nanoparticles in a Murine Model of Oral Candidiasis. Molecules. 2018; 23(8). PMC: 6222858. DOI: 10.3390/molecules23082075. View

Mima E, Pavarina A, Dovigo L, Vergani C, de Souza Costa C, Kurachi C . Susceptibility of Candida albicans to photodynamic therapy in a murine model of oral candidosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 109(3):392-401. DOI: 10.1016/j.tripleo.2009.10.006. View

Rodero C, Calixto G, Dos Santos K, Sato M, Dos Santos Ramos M, Miro M . Curcumin-Loaded Liquid Crystalline Systems for Controlled Drug Release and Improved Treatment of Vulvovaginal Candidiasis. Mol Pharm. 2018; 15(10):4491-4504. DOI: 10.1021/acs.molpharmaceut.8b00507. View

Liu W, Zhai Y, Heng X, Che F, Chen W, Sun D . Oral bioavailability of curcumin: problems and advancements. J Drug Target. 2016; 24(8):694-702. DOI: 10.3109/1061186X.2016.1157883. View

Pierce C, Srinivasan A, Uppuluri P, Ramasubramanian A, Lopez-Ribot J . Antifungal therapy with an emphasis on biofilms. Curr Opin Pharmacol. 2013; 13(5):726-30. PMC: 3795934. DOI: 10.1016/j.coph.2013.08.008. View

Kumar A, Dhamgaye S, Maurya I, Singh A, Sharma M, Prasad R . Curcumin targets cell wall integrity via calcineurin-mediated signaling in Candida albicans. Antimicrob Agents Chemother. 2013; 58(1):167-75. PMC: 3910804. DOI: 10.1128/AAC.01385-13. View

Yen F, Wu T, Tzeng C, Lin L, Lin C . Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities. J Agric Food Chem. 2010; 58(12):7376-82. DOI: 10.1021/jf100135h. View

10.

Akpan A, Morgan R . Oral candidiasis. Postgrad Med J. 2002; 78(922):455-9. PMC: 1742467. DOI: 10.1136/pmj.78.922.455. View

11.

Raouf M, Essa S, El Achy S, Essawy M, Rafik S, Baddour M . Evaluation of Combined Ciprofloxacin and azithromycin free and nano formulations to control biofilm producing Pseudomonas aeruginosa isolated from burn wounds. Indian J Med Microbiol. 2021; 39(1):81-87. DOI: 10.1016/j.ijmmb.2021.01.004. View

12.

Vidal Bonifacio B, da Silva P, Dos Santos Ramos M, Negri K, Bauab T, Chorilli M . Nanotechnology-based drug delivery systems and herbal medicines: a review. Int J Nanomedicine. 2013; 9:1-15. PMC: 3862741. DOI: 10.2147/IJN.S52634. View

13.

Mittal A, Kumar N, Chauhan N . Curcumin Encapsulated PEGylated Nanoliposomes: A Potential Anti-Infective Therapeutic Agent. Indian J Microbiol. 2019; 59(3):336-343. PMC: 6646638. DOI: 10.1007/s12088-019-00811-3. View

14.

Kunnumakkara A, Anand P, Aggarwal B . Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 2008; 269(2):199-225. DOI: 10.1016/j.canlet.2008.03.009. View

15.

Motterlini R, Foresti R, Bassi R, Green C . Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med. 2000; 28(8):1303-12. DOI: 10.1016/s0891-5849(00)00294-x. View

16.

Menon V, Sudheer A . Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol. 2007; 595:105-25. DOI: 10.1007/978-0-387-46401-5_3. View

17.

Pai V, Ganavalli A, Kikkeri N . Antifungal Resistance in Dermatology. Indian J Dermatol. 2018; 63(5):361-368. PMC: 6124242. DOI: 10.4103/ijd.IJD_131_17. View

18.

Salazar S, Simoes R, Pedro N, Pinheiro M, Carvalho M, Mira N . An Overview on Conventional and Non-Conventional Therapeutic Approaches for the Treatment of Candidiasis and Underlying Resistance Mechanisms in Clinical Strains. J Fungi (Basel). 2020; 6(1). PMC: 7151124. DOI: 10.3390/jof6010023. View

19.

Takakura N, Sato Y, Ishibashi H, Oshima H, Uchida K, Yamaguchi H . A novel murine model of oral candidiasis with local symptoms characteristic of oral thrush. Microbiol Immunol. 2003; 47(5):321-6. DOI: 10.1111/j.1348-0421.2003.tb03403.x. View

20.

Tverdek F, Kofteridis D, Kontoyiannis D . Antifungal agents and liver toxicity: a complex interaction. Expert Rev Anti Infect Ther. 2016; 14(8):765-76. DOI: 10.1080/14787210.2016.1199272. View