Paternal Imprinting of Dosage-effect Defective1 Contributes to Seed Weight Xenia in Maize

Overview

Journal Nat Commun

Specialty Biology

Date 2022 Sep 13

PMID 36100609

Authors

Dawei Dai

Janaki S Mudunkothge

Mary Galli

Si Nian Char

Ruth Davenport

Xiaojin Zhou

Jeffery L Gustin

Gertraud Spielbauer

Junya Zhang

W Brad Barbazuk

Bing Yang

Andrea Gallavotti

A Mark Settles

Affiliations

Soon will be listed here.

Abstract

Historically, xenia effects were hypothesized to be unique genetic contributions of pollen to seed phenotype, but most examples represent standard complementation of Mendelian traits. We identified the imprinted dosage-effect defective1 (ded1) locus in maize (Zea mays) as a paternal regulator of seed size and development. Hypomorphic alleles show a 5-10% seed weight reduction when ded1 is transmitted through the male, while homozygous mutants are defective with a 70-90% seed weight reduction. Ded1 encodes an R2R3-MYB transcription factor expressed specifically during early endosperm development with paternal allele bias. DED1 directly activates early endosperm genes and endosperm adjacent to scutellum cell layer genes, while directly repressing late grain-fill genes. These results demonstrate xenia as originally defined: Imprinting of Ded1 causes the paternal allele to set the pace of endosperm development thereby influencing grain set and size.

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