The Downregulated Drug-metabolism Related ALDH6A1 Serves As Predictor for Prognosis and Therapeutic Immune Response in Gastric Cancer

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2022 Sep 13

PMID 36098688

Authors

Yuan Cai

Rong Zeng

Jinwu Peng

Wei Liu

Qingchun He

Zhijie Xu

Ning Bai

Affiliations

Soon will be listed here.

Abstract

Drug metabolism-associated genes have been clarified to play a vital role in the process of cancer cell growth and migration. Nevertheless, the correlation between drug metabolism-associated genes and gastric cancer (GC) has not been fully explored and clarified. This paper has focused on the role of aldehyde dehydrogenase 6 family member A1 (ALDH6A1), a drug metabolism-associated gene, in the immune regulation and prognosis of GC patients. Using several bioinformatics platforms and immunohistochemistry (IHC) assay, we found that ALDH6A1 expression was significantly down-regulated in GC tissues. Moreover, higher expression of ALDH6A1 was related to the better prognosis of GC patients. ALDH6A1 was also found to be involved in the regulation of several immune-associated signatures, including immunoinhibitors. In conclusion, the above results have concluded that aberrant expression of ALDH6A1 might be served as the promising predictor for prognosis and clinical immunotherapy response in GC patients.

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