Fatty Acid-Binding Protein 3 Is a Marker of Neurodegeneration and White Matter Hyperintensity Burden in Mexican American Older Adults

Overview

Journal J Alzheimers Dis

Publisher Sage Publications

Specialties Geriatrics
Neurology

Date 2022 Sep 12

PMID 36093702

Authors

Alexandra L Clark

Andreana P Haley

Audrey Duarte

Sid OBryant

Affiliations

Soon will be listed here.

Abstract

We examined ethnoracial differences in fatty acid binding protein (FABP)-a family of intracellular lipid carriers-and clarified FABP3 associations with gray and white matter. Relative to Mexican Americans (MAs), FABP3 was higher in Non-Hispanic Whites (NHWS, p < 0.001). Regressions revealed, independent of traditional AD markers, FABP3 was associated with neurodegeneration (B = -0.08, p = 0.003) and WMH burden (B = 0.18, p = 0.03) in MAs, but not in NHWs (ps > 0.18). Findings suggest FABP3 is related to neural health within MAs and highlight its potential as a prognostic marker of brain health in ethnoracially diverse older adults.

Citing Articles

Heart fatty acid-binding protein is associated with phosphorylated tau and longitudinal cognitive changes.

Fu Y, Wang Z, Huang L, Tan C, Cao X, Tan L Front Aging Neurosci. 2022; 14:1008780.

PMID: 36299612 PMC: 9588952. DOI: 10.3389/fnagi.2022.1008780.

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