The Inflammatory Immune System After Wake Up in Healthy Male Individuals: A Highly Standardized and Controlled Study

Overview

Journal Brain Behav Immun Health

Date 2022 Sep 12

PMID 36093437

Authors

Katja Petrowski

Bjarne Schmalbach

Mona Linhardt

Liza Mekschrat

Nicolas Rohleder

Affiliations

Soon will be listed here.

Abstract

This study investigates the effects of two light conditions on innate proinflammatory IL-6 cytokines and the cortisol awakening response. The between-subject experiment was conducted with 55 healthy adult-males (aged = 24.40, SD = 4.58; = 25.47, SD = 4.96) in a standardized sleep laboratory setting with 60-min light exposure post-awakening. Cortisol significantly increased with bright light exposure as compared to dim light (significant interaction effect). As for IL-6, the main effects of time and light condition were significant, however, the interaction effect between light and time was insignificant. Results replicate stimulatory effects of bright light on cortisol. In general, IL-6 concentrations decreased in both light conditions; however, bright light graphically showed higher concentrations 45-90 min after exposure in comparison to dim light, thus bright light has a potential stimulatory effect on IL-6 production.

Citing Articles

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References

Petrowski K, Buehrer S, Niedling M, Schmalbach B . The effects of light exposure on the cortisol stress response in human males. Stress. 2020; 24(1):29-35. DOI: 10.1080/10253890.2020.1741543. View

Brodin P, Davis M . Human immune system variation. Nat Rev Immunol. 2016; 17(1):21-29. PMC: 5328245. DOI: 10.1038/nri.2016.125. View

Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S . The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta. 2011; 1813(5):878-88. DOI: 10.1016/j.bbamcr.2011.01.034. View

Provencio I, Rollag M, Castrucci A . Photoreceptive net in the mammalian retina. This mesh of cells may explain how some blind mice can still tell day from night. Nature. 2002; 415(6871):493. DOI: 10.1038/415493a. View

Tahkamo L, Partonen T, Pesonen A . Systematic review of light exposure impact on human circadian rhythm. Chronobiol Int. 2018; 36(2):151-170. DOI: 10.1080/07420528.2018.1527773. View

Ishida A, Mutoh T, Ueyama T, Bando H, Masubuchi S, Nakahara D . Light activates the adrenal gland: timing of gene expression and glucocorticoid release. Cell Metab. 2005; 2(5):297-307. DOI: 10.1016/j.cmet.2005.09.009. View

Morita T, Tokura H . The influence of different wavelengths of light on human biological rhythms. Appl Human Sci. 1998; 17(3):91-6. DOI: 10.2114/jpa.17.91. View

Chapman B, Khan A, Harper M, Stockman D, Fiscella K, Walton J . Gender, race/ethnicity, personality, and interleukin-6 in urban primary care patients. Brain Behav Immun. 2009; 23(5):636-42. PMC: 2694851. DOI: 10.1016/j.bbi.2008.12.009. View

Petrovsky N, Harrison L . Diurnal rhythmicity of human cytokine production: a dynamic disequilibrium in T helper cell type 1/T helper cell type 2 balance?. J Immunol. 1997; 158(11):5163-8. View

10.

Jung S, Kim N, Choi Y, Choi J, Choi Y, Heo Y . Effects of melatonin and green-wavelength LED light on the physiological stress and immunity of goldfish, Carassius auratus, exposed to high water temperature. Fish Physiol Biochem. 2016; 42(5):1335-46. DOI: 10.1007/s10695-016-0221-7. View

11.

Steensberg A, Fischer C, Keller C, Moller K, Pedersen B . IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab. 2003; 285(2):E433-7. DOI: 10.1152/ajpendo.00074.2003. View

12.

Hankins M, Peirson S, Foster R . Melanopsin: an exciting photopigment. Trends Neurosci. 2007; 31(1):27-36. DOI: 10.1016/j.tins.2007.11.002. View

13.

Temme L, Frumkes T . Rod-cone interaction in human scotopic visiion--III: Rods influence cone increment thresholds. Vision Res. 1977; 17(6):681-5. DOI: 10.1016/s0042-6989(77)80002-3. View

14.

Herhaus B, Ullmann E, Chrousos G, Petrowski K . High/low cortisol reactivity and food intake in people with obesity and healthy weight. Transl Psychiatry. 2020; 10(1):40. PMC: 7026436. DOI: 10.1038/s41398-020-0729-6. View

15.

Thorn L, Hucklebridge F, Esgate A, Evans P, Clow A . The effect of dawn simulation on the cortisol response to awakening in healthy participants. Psychoneuroendocrinology. 2004; 29(7):925-30. DOI: 10.1016/j.psyneuen.2003.08.005. View

16.

Ulrich-Lai Y, Arnhold M, Engeland W . Adrenal splanchnic innervation contributes to the diurnal rhythm of plasma corticosterone in rats by modulating adrenal sensitivity to ACTH. Am J Physiol Regul Integr Comp Physiol. 2005; 290(4):R1128-35. DOI: 10.1152/ajpregu.00042.2003. View

17.

Dickstein J, Moldofsky H . Sleep, cytokines and immune function. Sleep Med Rev. 2004; 3(3):219-28. DOI: 10.1016/s1087-0792(99)90003-5. View

18.

Jung C, Khalsa S, Scheer F, Cajochen C, Lockley S, Czeisler C . Acute effects of bright light exposure on cortisol levels. J Biol Rhythms. 2010; 25(3):208-16. PMC: 3686562. DOI: 10.1177/0748730410368413. View

19.

Hattar S, Lucas R, Mrosovsky N, Thompson S, Douglas R, Hankins M . Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature. 2003; 424(6944):76-81. PMC: 2885907. DOI: 10.1038/nature01761. View

20.

Pruessner J, Kirschbaum C, Meinlschmid G, Hellhammer D . Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology. 2003; 28(7):916-31. DOI: 10.1016/s0306-4530(02)00108-7. View