Electronic Cigarette and Atherosclerosis: A Comprehensive Literature Review of Latest Evidences

Overview

Journal Int J Vasc Med

Publisher Wiley

Specialty Cardiology & Vascular Diseases

Date 2022 Sep 12

PMID 36093338

Authors

Vito Anggarino Damay

Setiawan

Ronny Lesmana

M Rizki Akbar

Antonia Anna Lukito

Vita M Tarawan

Januar W Martha

J Nugroho

Affiliations

Soon will be listed here.

Abstract

Coronary artery diseases (CAD), also known as coronary heart disease (CHD), are the world's leading cause of death. The basis of coronary artery disease is the narrowing of the heart coronary artery lumen due to atherosclerosis. The use of electronic cigarettes has increased significantly over the years. However, harmful effects of electronic cigarettes are still not firm. The aim of this article is to review the impact of electronic cigarette and its role in the pathogenesis of atherosclerosis from recent studies. The results showed that several chemical compounds, such as nicotine, propylene glycol, particulate matters, heavy metals, and flavorings, in electronic cigarette induce atherosclerosis with each molecular mechanism that lead to atherosclerosis progression by formation of ROS, endothelial dysfunction, and inflammation. Further research is still needed to determine the exact mechanism and provide more clinical evidence.

Citing Articles

Sex-specific associations of cigarettes and e-cigarettes use with self-reported premature atherosclerotic cardiovascular disease among adults aged 18-54 in the United States.

Elo-Eghosa E, Li W, Ebrahimi Kalan M, Hu N, Osibogun O Prev Med. 2024; 190:108181.

PMID: 39557305 PMC: 11645184. DOI: 10.1016/j.ypmed.2024.108181.

Brazilian Society of Cardiology Position Statement on the Use of Electronic Nicotine Delivery Systems - 2024.

Scholz J, Malta D, Fagundes Junior A, Pavanello R, Bredt Junior G, Rocha M Arq Bras Cardiol. 2024; 121(2):e20240063.

PMID: 38422228 PMC: 11081107. DOI: 10.36660/abc.20240063.

Aerobic Exercise versus Electronic Cigarette in Vascular Aging Process: First Histological Insight.

Damay V, Setiawan , Lesmana R, Akbar M, Lukito A, Tarawan V Int J Vasc Med. 2023; 2023:8874599.

PMID: 37533734 PMC: 10393525. DOI: 10.1155/2023/8874599.

References

Holm Nielsen S, Jonasson L, Kalogeropoulos K, Karsdal M, Reese-Petersen A, Auf dem Keller U . Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome. J Intern Med. 2020; 287(5):493-513. DOI: 10.1111/joim.13034. View

Muthumalage T, Prinz M, Ansah K, Gerloff J, Sundar I, Rahman I . Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine. Front Physiol. 2018; 8:1130. PMC: 5768608. DOI: 10.3389/fphys.2017.01130. View

Libby P, Nahrendorf M, Swirski F . Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum". J Am Coll Cardiol. 2016; 67(9):1091-1103. PMC: 4779182. DOI: 10.1016/j.jacc.2015.12.048. View

Mayer M, Reyes-Guzman C, Grana R, Choi K, Freedman N . Demographic Characteristics, Cigarette Smoking, and e-Cigarette Use Among US Adults. JAMA Netw Open. 2020; 3(10):e2020694. PMC: 8094416. DOI: 10.1001/jamanetworkopen.2020.20694. View

Kondo T, Nakano Y, Adachi S, Murohara T . Effects of Tobacco Smoking on Cardiovascular Disease. Circ J. 2019; 83(10):1980-1985. DOI: 10.1253/circj.CJ-19-0323. View

Jackson A, Regine M, Subrata C, Long S . Molecular mechanisms and genetic regulation in atherosclerosis. Int J Cardiol Heart Vasc. 2018; 21:36-44. PMC: 6161413. DOI: 10.1016/j.ijcha.2018.09.006. View

Heidt T, Sager H, Courties G, Dutta P, Iwamoto Y, Zaltsman A . Chronic variable stress activates hematopoietic stem cells. Nat Med. 2014; 20(7):754-758. PMC: 4087061. DOI: 10.1038/nm.3589. View

Kaisar M, Villalba H, Prasad S, Liles T, Sifat A, Sajja R . Offsetting the impact of smoking and e-cigarette vaping on the cerebrovascular system and stroke injury: Is Metformin a viable countermeasure?. Redox Biol. 2017; 13:353-362. PMC: 5480985. DOI: 10.1016/j.redox.2017.06.006. View

Carnevale R, Sciarretta S, Violi F, Nocella C, Loffredo L, Perri L . Acute Impact of Tobacco vs Electronic Cigarette Smoking on Oxidative Stress and Vascular Function. Chest. 2016; 150(3):606-12. DOI: 10.1016/j.chest.2016.04.012. View

10.

Grana R, Benowitz N, Glantz S . E-cigarettes: a scientific review. Circulation. 2014; 129(19):1972-86. PMC: 4018182. DOI: 10.1161/CIRCULATIONAHA.114.007667. View

11.

Benowitz N, Burbank A . Cardiovascular toxicity of nicotine: Implications for electronic cigarette use. Trends Cardiovasc Med. 2016; 26(6):515-23. PMC: 4958544. DOI: 10.1016/j.tcm.2016.03.001. View

12.

Gerthoffer W . Mechanisms of vascular smooth muscle cell migration. Circ Res. 2007; 100(5):607-21. DOI: 10.1161/01.RES.0000258492.96097.47. View

13.

Farsalinos K, Kistler K, Gillman G, Voudris V . Evaluation of electronic cigarette liquids and aerosol for the presence of selected inhalation toxins. Nicotine Tob Res. 2014; 17(2):168-74. PMC: 4892705. DOI: 10.1093/ntr/ntu176. View

14.

Laukova M, Vargovic P, Csaderova L, Chovanova L, Vlcek M, Imrich R . Acute stress differently modulates β1, β2 and β3 adrenoceptors in T cells, but not in B cells, from the rat spleen. Neuroimmunomodulation. 2012; 19(2):69-78. DOI: 10.1159/000329002. View

15.

Cheng T . Chemical evaluation of electronic cigarettes. Tob Control. 2014; 23 Suppl 2:ii11-7. PMC: 3995255. DOI: 10.1136/tobaccocontrol-2013-051482. View

16.

Williams M, Villarreal A, Bozhilov K, Lin S, Talbot P . Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PLoS One. 2013; 8(3):e57987. PMC: 3603976. DOI: 10.1371/journal.pone.0057987. View

17.

Wu X, Zhang H, Qi W, Zhang Y, Li J, Li Z . Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis. Cell Death Dis. 2018; 9(2):171. PMC: 5833729. DOI: 10.1038/s41419-017-0257-3. View

18.

Anderson C, Majeste A, Hanus J, Wang S . E-Cigarette Aerosol Exposure Induces Reactive Oxygen Species, DNA Damage, and Cell Death in Vascular Endothelial Cells. Toxicol Sci. 2016; 154(2):332-340. DOI: 10.1093/toxsci/kfw166. View

19.

Lerner C, Sundar I, Watson R, Elder A, Jones R, Done D . Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols. Environ Pollut. 2015; 198:100-7. PMC: 4323666. DOI: 10.1016/j.envpol.2014.12.033. View

20.

Fatkhullina A, Peshkova I, Koltsova E . The Role of Cytokines in the Development of Atherosclerosis. Biochemistry (Mosc). 2016; 81(11):1358-1370. PMC: 5471837. DOI: 10.1134/S0006297916110134. View