Food Cue Reactivity in Successful Laparoscopic Gastric Banding: A Sham-deflation-controlled Pilot Study

Overview

Journal Front Hum Neurosci

Specialty Neurology

Date 2022 Sep 12

PMID 36092648

Authors

Marinka M G Koenis

Janet Ng

Beth Anderson

Michael C Stevens

Darren S Tishler

Pavlos K Papasavas

Andrea Stone

Tara McLaughlin

Allison Verhaak

Mirjana J Domakonda

Godfrey D Pearlson

Affiliations

Soon will be listed here.

Abstract

Laparoscopic adjustable gastric banding (LAGB) offers a unique opportunity to examine the underlying neuronal mechanisms of surgically assisted weight loss due to its instant, non-invasive, adjustable nature. Six participants with stable excess weight loss (%EWL ≥ 45) completed 2 days of fMRI scanning 1.5-5 years after LAGB surgery. In a within-subject randomized sham-controlled design, participants underwent (sham) removal of ∼ 50% of the band's fluid. Compared to sham-deflation (i.e., normal band constriction) of the band, in the deflation condition (i.e., decreasing restriction) participants showed significantly lower activation in the anterior (para)cingulate, angular gyrus, lateral occipital cortex, and frontal cortex in response to food images ( < 0.05, whole brain TFCE-based FWE corrected). Higher activation in the deflation condition was seen in the fusiform gyrus, inferior temporal gyrus, lingual gyrus, lateral occipital cortex. The findings of this within-subject randomized controlled pilot study suggest that constriction of the stomach through LAGB may indirectly alter brain activation in response to food cues. These neuronal changes may underlie changes in food craving and food preference that support sustained post-surgical weight-loss. Despite the small sample size, this is in agreement with and adds to the growing literature of post-bariatric surgery changes in behavior and control regions.

References

Hollmann M, Hellrung L, Pleger B, Schlogl H, Kabisch S, Stumvoll M . Neural correlates of the volitional regulation of the desire for food. Int J Obes (Lond). 2011; 36(5):648-55. DOI: 10.1038/ijo.2011.125. View

Martin L, Holsen L, Chambers R, Bruce A, Brooks W, Zarcone J . Neural mechanisms associated with food motivation in obese and healthy weight adults. Obesity (Silver Spring). 2009; 18(2):254-60. DOI: 10.1038/oby.2009.220. View

Gorgolewski K, Varoquaux G, Rivera G, Schwarz Y, Ghosh S, Maumet C . NeuroVault.org: a web-based repository for collecting and sharing unthresholded statistical maps of the human brain. Front Neuroinform. 2015; 9:8. PMC: 4392315. DOI: 10.3389/fninf.2015.00008. View

Hutch C, Sandoval D . The Role of GLP-1 in the Metabolic Success of Bariatric Surgery. Endocrinology. 2017; 158(12):4139-4151. PMC: 5711387. DOI: 10.1210/en.2017-00564. View

Murdaugh D, Cox J, Cook 3rd E, Weller R . fMRI reactivity to high-calorie food pictures predicts short- and long-term outcome in a weight-loss program. Neuroimage. 2012; 59(3):2709-21. PMC: 3287079. DOI: 10.1016/j.neuroimage.2011.10.071. View

Ness A, Bruce J, Bruce A, Aupperle R, Lepping R, Martin L . Pre-surgical cortical activation to food pictures is associated with weight loss following bariatric surgery. Surg Obes Relat Dis. 2014; 10(6):1188-95. DOI: 10.1016/j.soard.2014.06.005. View

Smith S, Jenkinson M, Woolrich M, Beckmann C, Behrens T, Johansen-Berg H . Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage. 2004; 23 Suppl 1:S208-19. DOI: 10.1016/j.neuroimage.2004.07.051. View

Flint A, Raben A, Blundell J, Astrup A . Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord. 2000; 24(1):38-48. DOI: 10.1038/sj.ijo.0801083. View

van Meer F, van der Laan L, Adan R, Viergever M, Smeets P . What you see is what you eat: an ALE meta-analysis of the neural correlates of food viewing in children and adolescents. Neuroimage. 2014; 104:35-43. DOI: 10.1016/j.neuroimage.2014.09.069. View

10.

DelParigi A, Chen K, Salbe A, Hill J, Wing R, Reiman E . Successful dieters have increased neural activity in cortical areas involved in the control of behavior. Int J Obes (Lond). 2006; 31(3):440-8. DOI: 10.1038/sj.ijo.0803431. View

11.

Goldstone A, Prechtl de Hernandez C, Beaver J, Muhammed K, Croese C, Bell G . Fasting biases brain reward systems towards high-calorie foods. Eur J Neurosci. 2009; 30(8):1625-35. DOI: 10.1111/j.1460-9568.2009.06949.x. View

12.

Smith S, Nichols T . Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage. 2008; 44(1):83-98. DOI: 10.1016/j.neuroimage.2008.03.061. View

13.

Bach P, Grosshans M, Koopmann A, Pfeifer A, Vollstadt-Klein S, Otto M . Predictors of weight loss in participants with obesity following bariatric surgery - A prospective longitudinal fMRI study. Appetite. 2021; 163:105237. DOI: 10.1016/j.appet.2021.105237. View

14.

Tang D, Fellows L, Small D, Dagher A . Food and drug cues activate similar brain regions: a meta-analysis of functional MRI studies. Physiol Behav. 2012; 106(3):317-24. DOI: 10.1016/j.physbeh.2012.03.009. View

15.

Brooks S, Cedernaes J, Schioth H . Increased prefrontal and parahippocampal activation with reduced dorsolateral prefrontal and insular cortex activation to food images in obesity: a meta-analysis of fMRI studies. PLoS One. 2013; 8(4):e60393. PMC: 3622693. DOI: 10.1371/journal.pone.0060393. View

16.

LaBar K, Gitelman D, Parrish T, Kim Y, Nobre A, Mesulam M . Hunger selectively modulates corticolimbic activation to food stimuli in humans. Behav Neurosci. 2001; 115(2):493-500. DOI: 10.1037/0735-7044.115.2.493. View

17.

Nock N, Dimitropolous A, Tkach J, Frasure H, von Gruenigen V . Reduction in neural activation to high-calorie food cues in obese endometrial cancer survivors after a behavioral lifestyle intervention: a pilot study. BMC Neurosci. 2012; 13:74. PMC: 3426465. DOI: 10.1186/1471-2202-13-74. View

18.

Guillaume B, Hua X, Thompson P, Waldorp L, Nichols T . Fast and accurate modelling of longitudinal and repeated measures neuroimaging data. Neuroimage. 2014; 94:287-302. PMC: 4073654. DOI: 10.1016/j.neuroimage.2014.03.029. View

19.

Goldman R, Canterberry M, Borckardt J, Madan A, Byrne T, George M . Executive control circuitry differentiates degree of success in weight loss following gastric-bypass surgery. Obesity (Silver Spring). 2013; 21(11):2189-2196. PMC: 4196691. DOI: 10.1002/oby.20575. View

20.

Koenis M, Papasavas P, Janssen R, Tishler D, Pearlson G . Brain responses to anticipatory cues and milkshake taste in obesity, and their relationship to bariatric surgery outcome. Neuroimage. 2021; 245:118623. PMC: 10947342. DOI: 10.1016/j.neuroimage.2021.118623. View