Gut Microbiota: A New Therapeutic Target for Diabetic Cardiomyopathy

Overview

Journal Front Pharmacol

Date 2022 Sep 12

PMID 36091756

Authors

Suxin Yuan

Zhengyao Cai

Xingzhao Luan

Haibo Wang

Yi Zhong

Li Deng

Jian Feng

Affiliations

Soon will be listed here.

Abstract

Diabetic cardiomyopathy seriously affects quality of life and even threatens life safety of patients. The pathogenesis of diabetic cardiomyopathy is complex and multifactorial, and it is widely accepted that its mechanisms include oxidative stress, inflammation, insulin resistance, apoptosis, and autophagy. Some studies have shown that gut microbiota plays an important role in cardiovascular diseases. Gut microbiota and its metabolites can affect the development of diabetic cardiomyopathy by regulating oxidative stress, inflammation, insulin resistance, apoptosis, and autophagy. Here, the mechanisms of gut microbiota and its metabolites resulting in diabetic cardiomyopathy are reviewed. Gut microbiota may be a new therapeutic target for diabetic cardiomyopathy.

Citing Articles

Multi-omics mechanical analysis of gut microbiota, carboxylic acids, and cardiac gene expression interaction triggering diabetic cardiomyopathy.

Shi M, Zhao B, Cai W, Yuan H, Liang X, Li Z mSystems. 2024; 10(1):e0145024.

PMID: 39611812 PMC: 11748484. DOI: 10.1128/msystems.01450-24.

Modulation of the Cardiovascular Risk in Type 1 Diabetic Rats by Endurance Training in Combination with the Prebiotic Xylooligosaccharide.

Choneva M, Delchev S, Hrischev P, Dimov I, Boyanov K, Dimitrov I Int J Mol Sci. 2024; 25(18).

PMID: 39337515 PMC: 11432573. DOI: 10.3390/ijms251810027.

Gut microbiota as a residual risk factor causally influencing cardiac structure and function: Mendelian randomization analysis and biological annotation.

Li Y, Yao M, Xie F, Qiu Y, Zhao X, Li R Front Microbiol. 2024; 15:1410272.

PMID: 39132134 PMC: 11316272. DOI: 10.3389/fmicb.2024.1410272.

Targeting gut microbiota in aging-related cardiovascular dysfunction: focus on the mechanisms.

Liu S, He Y, Zhang Y, Zhang Z, Huang K, Deng L Gut Microbes. 2023; 15(2):2290331.

PMID: 38073096 PMC: 10730151. DOI: 10.1080/19490976.2023.2290331.

Revitalizing myocarditis treatment through gut microbiota modulation: unveiling a promising therapeutic avenue.

Wang J, Zhang X, Yang X, Yu H, Bu M, Fu J Front Cell Infect Microbiol. 2023; 13:1191936.

PMID: 37260696 PMC: 10229058. DOI: 10.3389/fcimb.2023.1191936.

References

Jia G, Demarco V, Sowers J . Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol. 2015; 12(3):144-53. PMC: 4753054. DOI: 10.1038/nrendo.2015.216. View

Gu J, Wang S, Guo H, Tan Y, Liang Y, Feng A . Inhibition of p53 prevents diabetic cardiomyopathy by preventing early-stage apoptosis and cell senescence, reduced glycolysis, and impaired angiogenesis. Cell Death Dis. 2018; 9(2):82. PMC: 5833384. DOI: 10.1038/s41419-017-0093-5. View

Bastos R, Simplicio-Filho A, Savio-Silva C, Oliveira L, Cruz G, Sousa E . Fecal Microbiota Transplant in a Pre-Clinical Model of Type 2 Diabetes Mellitus, Obesity and Diabetic Kidney Disease. Int J Mol Sci. 2022; 23(7). PMC: 8998923. DOI: 10.3390/ijms23073842. View

Dumitrescu L, Popescu-Olaru I, Cozma L, Tulba D, Hinescu M, Ceafalan L . Oxidative Stress and the Microbiota-Gut-Brain Axis. Oxid Med Cell Longev. 2019; 2018:2406594. PMC: 6304899. DOI: 10.1155/2018/2406594. View

Kannel W, Hjortland M, CASTELLI W . Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol. 1974; 34(1):29-34. DOI: 10.1016/0002-9149(74)90089-7. View

Shi P, Zhao X, Shi K, Ding X, Tao H . MiR-21-3p triggers cardiac fibroblasts pyroptosis in diabetic cardiac fibrosis via inhibiting androgen receptor. Exp Cell Res. 2021; 399(2):112464. DOI: 10.1016/j.yexcr.2020.112464. View

Rajilic-Stojanovic M, Heilig H, Tims S, Zoetendal E, de Vos W . Long-term monitoring of the human intestinal microbiota composition. Environ Microbiol. 2013; . DOI: 10.1111/1462-2920.12023. View

Dewanjee S, Vallamkondu J, Kalra R, John A, Reddy P, Kandimalla R . Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy. Ageing Res Rev. 2021; 68:101338. DOI: 10.1016/j.arr.2021.101338. View

Saito K, Suzuki R, Koyanagi Y, Isogai H, Yoneyama H, Isogai E . Inhibition of enterohemorrhagic O157:H7 infection in a gnotobiotic mouse model with pre-colonization by strains. Biomed Rep. 2019; 10(3):175-182. PMC: 6403472. DOI: 10.3892/br.2019.1193. View

10.

Chang P, Hao L, Offermanns S, Medzhitov R . The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A. 2014; 111(6):2247-52. PMC: 3926023. DOI: 10.1073/pnas.1322269111. View

11.

Yuan T, Yang T, Chen H, Fu D, Hu Y, Wang J . New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis. Redox Biol. 2018; 20:247-260. PMC: 6205410. DOI: 10.1016/j.redox.2018.09.025. View

12.

Tang W, Li D, Hazen S . Dietary metabolism, the gut microbiome, and heart failure. Nat Rev Cardiol. 2018; 16(3):137-154. PMC: 6377322. DOI: 10.1038/s41569-018-0108-7. View

13.

Glazer H, Osipov R, Clements R, Sellke F, Bianchi C . Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling. Cell Cycle. 2009; 8(11):1738-46. PMC: 3308015. DOI: 10.4161/cc.8.11.8619. View

14.

Turnbaugh P, Ley R, Mahowald M, Magrini V, Mardis E, Gordon J . An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444(7122):1027-31. DOI: 10.1038/nature05414. View

15.

Sayin S, Wahlstrom A, Felin J, Jantti S, Marschall H, Bamberg K . Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013; 17(2):225-35. DOI: 10.1016/j.cmet.2013.01.003. View

16.

Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T . The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun. 2013; 4:1829. PMC: 3674247. DOI: 10.1038/ncomms2852. View

17.

Mizushima N . The pleiotropic role of autophagy: from protein metabolism to bactericide. Cell Death Differ. 2005; 12 Suppl 2:1535-41. DOI: 10.1038/sj.cdd.4401728. View

18.

Vrieze A, van Nood E, Holleman F, Salojarvi J, Kootte R, Bartelsman J . Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012; 143(4):913-6.e7. DOI: 10.1053/j.gastro.2012.06.031. View

19.

Palm N, de Zoete M, Flavell R . Immune-microbiota interactions in health and disease. Clin Immunol. 2015; 159(2):122-127. PMC: 4943041. DOI: 10.1016/j.clim.2015.05.014. View

20.

Su D, Ju Y, Han W, Yang Y, Wang F, Wang T . Tcf3-activated lncRNA Gas5 regulates newborn mouse cardiomyocyte apoptosis in diabetic cardiomyopathy. J Cell Biochem. 2020; 121(11):4337-4346. DOI: 10.1002/jcb.29630. View