Tao-Hong-Si-Wu Decoction Improves Depressive Symptoms in Model Rats Via Amelioration of BDNF-CREB-arginase I Axis Disorders

Overview

Journal Pharm Biol

Specialties Pharmacology
Pharmacy

Date 2022 Sep 12

PMID 36089851

Authors

Xiaoping Zhang

Zeng Li

Chuanpu Shen

Jinzhi He

Longfei Wang

Lei Di

Bin Rui

Ning Li

Zhicheng Liu

Affiliations

Soon will be listed here.

Abstract

Context: The traditional Chinese medicine formula Tao-Hong-Si-Wu decoction (TSD), used for treating ischaemic stroke, has the potential to treat depressive disorder (DD).

Objective: To explore the effective targets of TSD on DD animal models.

Materials And Methods: Sprague-Dawley (SD) rats were modelled by inducing chronic unpredictable mild stress (CUMS) during 35 days and treated with three dosages of TSD (2.5, 5 and 10 g/kg) or fluoxetine (10 mg/kg) by oral gavage for 14 days. Bodyweight measurements and behavioural tests were performed to observe the effect of TSD on the CUMS animals. A gas chromatography coupled with mass spectrometry (GC-MS)-based metabolomic analysis was conducted to reveal the metabolic characteristics related to the curative effect of TSD. Levels of the proteins associated with the feature metabolites were analysed.

Results: Reduced immobile duration and crossed squares in the behavioural tests were raised by 48.6% and 32.9%, on average, respectively, by TSD treatment (ED=3.2 g/kg). Antidepressant effects of TSD were associated with 13 decreased metabolites and the restorations of ornithine and urea in the serum. TSD (5 g/kg) raised serum serotonin by 54.1 mg/dL but suppressed arginase I (Arg I) by 47.8 mg/dL in the CUMS rats. Proteins on the brain-derived neurotrophic factor (BDNF)-cAMP response element-binding protein (CREB) axis that modulate the inhibition of Arg I were suppressed in the CUMS rats but reversed by the TSD intervention.

Discussion And Conclusions: TSD improves depression-like symptoms in CUMS rats. Further study will focus on the antidepressant-like effects of effective compounds contained in TSD.

References

Malhi G, Mann J . Depression. Lancet. 2018; 392(10161):2299-2312. DOI: 10.1016/S0140-6736(18)31948-2. View

Yeung W, Chung K, Ng K, Yu Y, Zhang S, Ng B . Prescription of Chinese Herbal Medicine in Pattern-Based Traditional Chinese Medicine Treatment for Depression: A Systematic Review. Evid Based Complement Alternat Med. 2015; 2015:160189. PMC: 4477207. DOI: 10.1155/2015/160189. View

Pang Z, Chong J, Zhou G, Morais D, Chang L, Barrette M . MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights. Nucleic Acids Res. 2021; 49(W1):W388-W396. PMC: 8265181. DOI: 10.1093/nar/gkab382. View

Xi S, Shi M, Jiang X, Minuk G, Cheng Y, Peng Y . The effects of Tao-Hong-Si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease. J Ethnopharmacol. 2016; 180:28-36. DOI: 10.1016/j.jep.2016.01.030. View

Cho Y, Hwang H, Rahman M, Chung C, Rhim H . Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex. Sci Rep. 2020; 10(1):6924. PMC: 7181662. DOI: 10.1038/s41598-020-63819-6. View

Zhang L, Yang Y, Di L, Li J, Li N . Erxian decoction, a famous Chinese medicine formula, antagonizes corticosterone-induced injury in PC12 cells, and improves depression-like behaviours in mice. Pharm Biol. 2020; 58(1):498-509. PMC: 8641676. DOI: 10.1080/13880209.2020.1765812. View

Sun K, Jin Y, Mei Z, Feng Z, Liu J, Cao M . Antidepressant-Like Effects of Chaihu Shugan Powder () on Rats Exposed to Chronic Unpredictable Mild Stress through Inhibition of Endoplasmic Reticulum Stress-Induced Apoptosis. Chin J Integr Med. 2020; 27(5):353-360. DOI: 10.1007/s11655-020-3228-y. View

Li L, Yang N, Nin L, Zhao Z, Chen L, Yu J . Chinese herbal medicine formula tao hong si wu decoction protects against cerebral ischemia-reperfusion injury via PI3K/Akt and the Nrf2 signaling pathway. J Nat Med. 2014; 69(1):76-85. DOI: 10.1007/s11418-014-0865-5. View

Kim Y, Na K, Shin K, Jung H, Choi S, Kim J . Cytokine imbalance in the pathophysiology of major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31(5):1044-53. DOI: 10.1016/j.pnpbp.2007.03.004. View

10.

Zeni A, Camargo A, Dalmagro A . Ferulic acid reverses depression-like behavior and oxidative stress induced by chronic corticosterone treatment in mice. Steroids. 2017; 125:131-136. DOI: 10.1016/j.steroids.2017.07.006. View

11.

Wang Y, Shen C, Jiang J . Antidepressant active ingredients from herbs and nutraceuticals used in TCM: pharmacological mechanisms and prospects for drug discovery. Pharmacol Res. 2019; 150:104520. DOI: 10.1016/j.phrs.2019.104520. View

12.

Yu H, Chen Z . The role of BDNF in depression on the basis of its location in the neural circuitry. Acta Pharmacol Sin. 2010; 32(1):3-11. PMC: 4003317. DOI: 10.1038/aps.2010.184. View

13.

Kostev K, Jacob L, Kalder M . Risk of depression, anxiety, and adjustment disorders in women with a suspected but unconfirmed diagnosis of breast or genital organ cancer in Germany. Cancer Causes Control. 2017; 28(10):1021-1026. DOI: 10.1007/s10552-017-0948-1. View

14.

Tuyiringire N, Tusubira D, Munyampundu J, Tolo C, Muvunyi C, Ogwang P . Application of metabolomics to drug discovery and understanding the mechanisms of action of medicinal plants with anti-tuberculosis activity. Clin Transl Med. 2018; 7(1):29. PMC: 6165828. DOI: 10.1186/s40169-018-0208-3. View

15.

Wang X, Ren J, Zhang A, Sun H, Yan G, Han Y . Novel applications of mass spectrometry-based metabolomics in herbal medicines and its active ingredients: Current evidence. Mass Spectrom Rev. 2019; 38(4-5):380-402. DOI: 10.1002/mas.21589. View

16.

Tao T, He T, Mao H, Wu X, Liu X . Non-Targeted Metabolomic Profiling of Coronary Heart Disease Patients With Taohong Siwu Decoction Treatment. Front Pharmacol. 2020; 11:651. PMC: 7227603. DOI: 10.3389/fphar.2020.00651. View

17.

Lee Y, Kim H, Lee C, Hyun S, Ko M, Lee B . 2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway. Int J Mol Sci. 2020; 21(23). PMC: 7729630. DOI: 10.3390/ijms21239103. View

18.

Cao B, Deng R, Wang D, Li L, Ren Z, Xu L . Association between arginine catabolism and major depressive disorder: A protocol for the systematic review and meta-analysis of metabolic pathway. Medicine (Baltimore). 2020; 99(27):e21068. PMC: 7337538. DOI: 10.1097/MD.0000000000021068. View

19.

Liu L, Dong Y, Shan X, Li L, Xia B, Wang H . Anti-Depressive Effectiveness of Baicalin In Vitro and In Vivo. Molecules. 2019; 24(2). PMC: 6359445. DOI: 10.3390/molecules24020326. View

20.

Ahmed T, Vasiliadis H . Global cognition modifies the relationship between anemia and depression in old age: A longitudinal analysis of the IMIAS Study. Arch Gerontol Geriatr. 2021; 94:104342. DOI: 10.1016/j.archger.2021.104342. View