Pharmacokinetics of Sulfadoxine and Pyrimethamine After Fansidar Administration in Man

Overview

Journal Chemotherapy

Specialty Pharmacology

Date 1987 Jan 1

PMID 3608621

Citations 11

Authors

M D Edstein

Affiliations

Soon will be listed here.

Abstract

The pharmacokinetics of sulfadoxine (SULF) and pyrimethamine (PYR) were studied in 7 healthy volunteers after a single oral dose of Fansidar. A comparison was made between the pharmacokinetics of the components of Fansidar calculated from whole blood and plasma data. The mean whole blood to plasma concentration ratios of SULF and PYR were 0.62 and 0.87, respectively. The elimination half-lives of SULF and PYR were similar in whole blood and plasma. The apparent volume of distribution and clearance of SULF and PYR in whole blood were significantly higher (p less than 0.01) than the corresponding plasma values. Because malaria-infected erythrocytes appear to concentrate SULF, it may be more relevant to measure drug concentrations in whole blood rather than in plasma in assessing the antimalarial efficacy of Fansidar.

Citing Articles

A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators.

Yang Y, Zhang Z, Li P, Kong W, Liu X, Liu L Pharmaceutics. 2021; 13(5).

PMID: 34064886 PMC: 8151202. DOI: 10.3390/pharmaceutics13050698.

A Physiologically-Based Pharmacokinetic Framework for Prediction of Drug Exposure in Malnourished Children.

Sjogren E, Tarning J, Barnes K, Jonsson E Pharmaceutics. 2021; 13(2).

PMID: 33540928 PMC: 7913226. DOI: 10.3390/pharmaceutics13020204.

Parasitologic Assessment of Two-Dose and Monthly Intermittent Preventive Treatment of Malaria during Pregnancy with Sulphadoxine-Pyrimethamine (IPTP-SP) in Lagos, Nigeria.

Agomo C, Oyibo W, Odukoya-Maije F Malar Res Treat. 2012; 2011:932895.

PMID: 22312575 PMC: 3265291. DOI: 10.4061/2011/932895.

Residual antimalarials in malaria patients from Tanzania--implications on drug efficacy assessment and spread of parasite resistance.

Hodel E, Kabanywanyi A, Malila A, Zanolari B, Mercier T, Beck H PLoS One. 2009; 4(12):e8184.

PMID: 20011529 PMC: 2788605. DOI: 10.1371/journal.pone.0008184.

Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant women.

Karunajeewa H, Salman S, Mueller I, Baiwog F, Gomorrai S, Law I Antimicrob Agents Chemother. 2009; 53(10):4368-76.

PMID: 19620325 PMC: 2764169. DOI: 10.1128/AAC.00335-09.