Xin-Ji-Er-Kang Protects Heart from Ischemia-reperfusion Injury by Rebalancing Lipid Metabolism

Overview

Journal Front Pharmacol

Date 2022 Sep 9

PMID 36081937

Authors

Li-Jun Sun

Xiao-Yu Wang

Jie Xia

Yan-Mei Xu

Yu-Feng Liao

Yuan-Yuan Qin

Xue-Wan Ge

Pei-Wen Zhao

Tong Xu

Xiao-Ling Zhu

Shan Gao

Rui Xiao

Xue-Sheng Liu

Kai Zhou

Affiliations

Soon will be listed here.

Abstract

We have previously reported a cardioprotective effect with Xin-Ji-Er-Kang (XJEK) treatment in mice with myocardial infarction (MI)-induced heart failure, but no report about its potential functions in myocardial ischemia-reperfusion (MIR) injury. Here we studied the therapeutic effects of XJEK on MIR injury and investigated the mechanisms involved. MIR model of Balb/c mice induced by left anterior descending coronary artery ligation for half an hour, followed by reperfusion, was utilized to study the potential therapeutic effects of XJEK on MIR-induced cardiac injury. Ultra-performance liquid chromatography tandem Orbitrap mass spectrometry platform was used for studying serum lipid metabolic signatures. MIR caused cardiac dysfunctions, cardiac injury, myocardial fibrosis, and increased inflammation, and all the observed abnormalities caused by MIR were largely corrected by XJEK treatment. Mechanistically, XJEK exerts its cardioprotective effect in the context of MIR injury by suppressing MIR-induced inflammation and dysregulation of serum lipid metabolism. We have demonstrated for the first time that XJEK protects heart from MIR injury by restoring dysregulated lipidomics. Our data provide new evidence to support a therapeutic effect for XIEK on MIR-induced cardiac injury, and pave the way for exploring the therapeutic potential of XJEK in large animal study and early clinical trial.

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