Metabolomic Analysis and MRM Verification of Coarse and Fine Skin Tissues of Liaoning Cashmere Goat

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 Sep 9

PMID 36080249

Authors

Yanan Xu

Weidong Cai

Rui Chen

Xinjiang Zhang

Zhixian Bai

Yu Zhang

Yuting Qin

Ming Gu

Yinggang Sun

Yanzhi Wu

Zeying Wang

Affiliations

Soon will be listed here.

Abstract

One of the critical elements in evaluating the quality of cashmere is its fineness, but we still know little about how it is regulated at the metabolic level. In this paper, we use UHPLC-MS/MS detection and analysis technology to compare the difference in metabolites between coarse cashmere (CT_LCG) and fine cashmere (FT_LCG) skin of Liaoning cashmere goats. According to the data, under positive mode four metabolites were significantly up-regulated and seven were significantly down-regulated. In negative mode, seven metabolites were significantly up-regulated and fourteen metabolites were significantly down-regulated. The two groups' most significant metabolites, Gly-Phe and taurochenodeoxycholate, may be crucial in controlling cashmere's growth, development, and fineness. In addition, we enriched six KEGG pathways, of which cholesterol metabolism, primary bile acid biosynthesis, and bile secretion were enriched in positive and negative modes. These findings offer a new research idea for further study into the critical elements influencing cashmere's fineness.

Citing Articles

Correlation and regression analysis of FA2H and ELOVL3 functional genes for cashmere fineness with production performance in Liaoning cashmere goat.

Li S, Kong L, Li S, Liu Y, Pan Y, Liu Q J Genet Eng Biotechnol. 2024; 22(4):100430.

PMID: 39674643 PMC: 11533662. DOI: 10.1016/j.jgeb.2024.100430.

Multi-omics analysis of functional substances and expression verification in cashmere fineness.

Xu Y, Zhang Y, Qin Y, Gu M, Chen R, Sun Y BMC Genomics. 2023; 24(1):720.

PMID: 38017403 PMC: 10685610. DOI: 10.1186/s12864-023-09825-0.

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