Association of Rs9679162 Genetic Polymorphism and Aberrant Expression of Polypeptide in Head and Neck Cancer

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2022 Sep 9

PMID 36077753

Authors

Nan-Chin Lin

Yin-Hwa Shih

Kuo-Chou Chiu

Po-Jung Li

Hui-Wu Yang

Wan-Chen Lan

Shih-Min Hsia

Tong-Hong Wang

Tzong-Ming Shieh

Affiliations

Soon will be listed here.

Abstract

The polypeptide rs9679162 and mRNA expression were associated with treatment outcome in various cancers. However, the relation of and head and neck cancer were nuclear. A total of 199 patients with head and neck squamous cell carcinoma (HNSCC) were collected in this study, including oral SCC (OSCC), oropharyngeal SCC (OPSCC), laryngeal SCC (LSCC), and others. The DNA and RNA of cancer tissues were extracted using the TRI Reagent method. The rs9679162 was analyzed using polymerase chain reaction (PCR) and sequencing methods in 199 DNA specimens, and the mRNA expression was analyzed using quantitative reverse transcription PCR (RT-qPCR) methods in 68 paired RNA specimens of non-cancerous matched tissues (NCMT) and tumor tissues. The results showed that the genotype of TT, TG, and GG appeared at 30%, 44%, and 26%, respectively. Non-TT genotype or G alleotype were associated with alcohol, betel nut, and cigarette using among patients with OSCC, and it also affected the treatment and survival of patients with OSCC and LSCC. High mRNA expression levels increased lymphatic metastasis of patients with HNSCC, and treatment and survival in patients with OPSCC. Overall, the -rs9679162 genotype and mRNA expression level can be used as indicators of HNSCC treatment prognosis.

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