Autologous Platelet Concentrates for Facial Rejuvenation

Overview

Journal J Appl Oral Sci

Specialty Dentistry

Date 2022 Sep 8

PMID 36074433

Authors

Marilia Afonso Rabelo Buzalaf

Flavia Mauad Levy

Affiliations

Soon will be listed here.

Abstract

Background: Autologous platelet concentrates (APCs) are promising therapeutic agents in facial rejuvenation since they are a great source of cytokines, growth factors and other biologically active substances. Obtained from the patient's blood, they have the advantages of reducing immunological reactions, making the procedure safer, well tolerated, with minimal adverse effects and lower cost. Currently, they are used for facial rejuvenation both in combination with microneedling and in mesotherapy techniques, as well as to treat facial acne scars, melasma and wounds after laser ablative treatments. This review summarizes current knowledge on the use of APCs, ranging from basic concepts related to their composition and mechanisms of action to up-to-date information on their clinical efficacy.

Methodology: MEDLINE (PubMed) was searched from inception through 2021 for English language publications on APCs for facial rejuvenation.

Results: A total of 100 files were found. Based on the available literature, APCs for skin rejuvenation are safe and well tolerated. The most studied product is the first-generation material, platelet-rich plasma (PRP).

Conclusions: The results are in general favorable, but the quality of the studies is low. The second and third generation products, platelet-rich fibrin (PRF) and injectable platelet-rich fibrin (i-PRF), respectively, are easier to be obtained and, at least in vitro , seem to induce greater collagen production than PRP, especially under lower relative centrifugation forces, but to date only a few clinical trials evaluating these products exist. More high-quality trials with appropriate follow-up are necessary to provide adequate evidence that may help to improve the treatment regimens with APCs. Many aspects should be considered when designing clinical trials to evaluate APCs, such as the patients' characteristics that best predict a favorable response, the optimal number of sessions and the interval between them, the characteristics of the studies and the development of better instruments to evaluate skin aging.

Citing Articles

An International Survey on the Use of a Polyrevitalizing Solution With or Without Other Aesthetic Procedures in the Daily Practice of Aesthetic Physicians.

Fanian F, Casabona G, Bartoletti E, Cartier H, Landau M, Galadari H J Cosmet Dermatol. 2025; 24(2):e16623.

PMID: 39840703 PMC: 11837238. DOI: 10.1111/jocd.16623.

Platelet-rich plasma alleviates skin photoaging by activating autophagy and inhibiting inflammasome formation.

Huang Z, Gu Z, Zeng Y, Zhang D Naunyn Schmiedebergs Arch Pharmacol. 2025; .

PMID: 39836253 DOI: 10.1007/s00210-025-03800-0.

Impact of regenerative procedure on the healing process following surgical root canal treatment: A systematic review and meta-analysis.

Muthanna N, Guan X, Alzahrani F, Saif B, Seyam A, Alsalman A PLoS One. 2025; 20(1):e0312751.

PMID: 39746110 PMC: 11695025. DOI: 10.1371/journal.pone.0312751.

L-PRF in extra-oral wound care.

Pinto N, Yu J, Koirala S, Mourao C, Andrade C, Rescigno E Periodontol 2000. 2024; 97(1):342-362.

PMID: 39305000 PMC: 11808448. DOI: 10.1111/prd.12605.

Systematic Review of Platelet-Rich Plasma in Medical and Surgical Specialties: Quality, Evaluation, Evidence, and Enforcement.

Rahman E, Rao P, Abu-Farsakh H, Thonse C, Ali I, Upton A J Clin Med. 2024; 13(15).

PMID: 39124838 PMC: 11313071. DOI: 10.3390/jcm13154571.

References

Cho E, Park G, Park S, Jang Y, Kim K, Kim K . Effect of platelet-rich plasma on proliferation and migration in human dermal fibroblasts. J Cosmet Dermatol. 2018; 18(4):1105-1112. DOI: 10.1111/jocd.12780. View

Knighton D, Ciresi K, Fiegel V, Austin L, Butler E . Classification and treatment of chronic nonhealing wounds. Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg. 1986; 204(3):322-30. PMC: 1251286. DOI: 10.1097/00000658-198609000-00011. View

da Silva L, Cancela R, Montalvao S, Huber S, Vieira-Damiani G, Triglia R . The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial. Arch Dermatol Res. 2021; 313(10):863-871. DOI: 10.1007/s00403-021-02186-2. View

Magalon J, Bausset O, Serratrice N, Giraudo L, Aboudou H, Veran J . Characterization and comparison of 5 platelet-rich plasma preparations in a single-donor model. Arthroscopy. 2014; 30(5):629-38. DOI: 10.1016/j.arthro.2014.02.020. View

El Bagdadi K, Kubesch A, Yu X, Al-Maawi S, Orlowska A, Dias A . Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept). Eur J Trauma Emerg Surg. 2017; 45(3):467-479. PMC: 6579868. DOI: 10.1007/s00068-017-0785-7. View

Uysal C, Ertas N . Platelet-Rich Plasma Increases Pigmentation. J Craniofac Surg. 2016; 28(8):e793. DOI: 10.1097/SCS.0000000000002893. View

Cameli N, Mariano M, Cordone I, Abril E, Masi S, Foddai M . Autologous Pure Platelet-Rich Plasma Dermal Injections for Facial Skin Rejuvenation: Clinical, Instrumental, and Flow Cytometry Assessment. Dermatol Surg. 2017; 43(6):826-835. DOI: 10.1097/DSS.0000000000001083. View

Hersant B, SidAhmed-Mezi M, Aboud C, Niddam J, Levy S, Mernier T . Synergistic Effects of Autologous Platelet-Rich Plasma and Hyaluronic Acid Injections on Facial Skin Rejuvenation. Aesthet Surg J. 2021; 41(7):NP854-NP865. DOI: 10.1093/asj/sjab061. View

Sclafani A, Azzi J . Platelet Preparations for Use in Facial Rejuvenation and Wound Healing: A Critical Review of Current Literature. Aesthetic Plast Surg. 2015; 39(4):495-505. DOI: 10.1007/s00266-015-0504-x. View

10.

Lee Z, Sinno S, Poudrier G, Motosko C, Chiodo M, Saia W . Platelet rich plasma for photodamaged skin: A pilot study. J Cosmet Dermatol. 2018; 18(1):77-83. DOI: 10.1111/jocd.12676. View

11.

Na J, Choi J, Choi H, Jeong J, Park K, Youn S . Rapid healing and reduced erythema after ablative fractional carbon dioxide laser resurfacing combined with the application of autologous platelet-rich plasma. Dermatol Surg. 2011; 37(4):463-8. DOI: 10.1111/j.1524-4725.2011.01916.x. View

12.

Pancar Yuksel E, Sahin G, Aydin F, Senturk N, Turanli A . Evaluation of effects of platelet-rich plasma on human facial skin. J Cosmet Laser Ther. 2014; 16(5):206-8. DOI: 10.3109/14764172.2014.949274. View

13.

Cho J, Kim S, Lee K . Platelet-rich plasma induces increased expression of G1 cell cycle regulators, type I collagen, and matrix metalloproteinase-1 in human skin fibroblasts. Int J Mol Med. 2011; 29(1):32-6. DOI: 10.3892/ijmm.2011.803. View

14.

Diab H, Elhosseiny R, Bedair N, Khorkhed A . Efficacy and safety of plasma gel versus platelet-rich plasma in periorbital rejuvenation: a comparative split-face clinical and Antera 3D camera study. Arch Dermatol Res. 2021; 314(7):661-671. DOI: 10.1007/s00403-021-02270-7. View

15.

Mehryan P, Zartab H, Rajabi A, Pazhoohi N, Firooz A . Assessment of efficacy of platelet-rich plasma (PRP) on infraorbital dark circles and crow's feet wrinkles. J Cosmet Dermatol. 2014; 13(1):72-8. DOI: 10.1111/jocd.12072. View

16.

Choukroun J, Ghanaati S . Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients' own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg. 2017; 44(1):87-95. PMC: 5808086. DOI: 10.1007/s00068-017-0767-9. View

17.

Marx R . Platelet-rich plasma (PRP): what is PRP and what is not PRP?. Implant Dent. 2002; 10(4):225-8. DOI: 10.1097/00008505-200110000-00002. View

18.

Redaelli A, Romano D, Marciano A . Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol. 2010; 9(5):466-72. View

19.

Jenkins G . Molecular mechanisms of skin ageing. Mech Ageing Dev. 2002; 123(7):801-10. DOI: 10.1016/s0047-6374(01)00425-0. View

20.

Gawdat H, Allam R, Hegazy R, Sameh B, Ragab N . Comparison of the efficacy of Fractional Radiofrequency Microneedling alone and in combination with platelet-rich plasma in neck rejuvenation: a clinical and optical coherence tomography study. J Cosmet Dermatol. 2021; 21(5):2038-2045. DOI: 10.1111/jocd.14331. View