Novel Advances in Strategies and Applications of Artificial Articular Cartilage

Overview

Journal Front Bioeng Biotechnol

Date 2022 Sep 8

PMID 36072291

Authors

Yifei Chen

Chenyue Zhang

Shiyong Zhang

Hexu Qi

Donghui Zhang

Yifei Li

Jie Fang

Affiliations

Soon will be listed here.

Abstract

Artificial articular cartilage (AC) is extensively applied in the repair and regeneration of cartilage which lacks self-regeneration capacity because of its avascular and low-cellularity nature. With advances in tissue engineering, bioengineering techniques for artificial AC construction have been increasing and maturing gradually. In this review, we elaborated on the advances of biological scaffold technologies in artificial AC including freeze-drying, electrospinning, 3D bioprinting and decellularized, and scaffold-free methods such as self-assembly and cell sheet. In the following, several successful applications of artificial AC built by scaffold and scaffold-free techniques are introduced to demonstrate the clinical application value of artificial AC.

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