Roles of ABCA1 in Cancer

Overview

Journal Oncol Lett

Specialty Oncology

Date 2022 Sep 8

PMID 36072007

Authors

Kun Wu

Longwei Zou

Xiaoyong Lei

Xiaoyan Yang

Affiliations

Soon will be listed here.

Abstract

Studies have indicated that anticancer drugs targeting cholesterol metabolism have clinical significance. From the perspective of the mechanism of cholesterol excretion from cells, ATP-binding cassette (ABC)A1 has an essential role that cannot be ignored. ABCA1 is located on the cell membrane and able to mediate the efflux of lipids, such as intracellular cholesterol, thereby initiating reverse cholesterol transport to reduce the intracellular cholesterol level. Therefore, inducing the expression of ABCA1 may become a new breakthrough point in cancer therapy.

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