Effects of Proportions of Carbohydrates and Fats in Diets on Mucin Concentration and Bile Composition in Gallbladder of Dogs

Overview

Journal J Vet Med Sci

Specialty Veterinary Medicine

Date 2022 Sep 7

PMID 36070935

Authors

Riho Shikano

Koichi Ohno

Takuro Nagahara

Itsuma Nagao

Hiroto Toyoda

Taisuke Nakagawa

Yuko Goto-Koshino

James K Chambers

Hirotaka Tomiyasu

Hajime Tsujimoto

Affiliations

Soon will be listed here.

Abstract

The associations of diet compositions with mucin secretion in gallbladder have not been investigated in dogs. This study aimed to examine the effects of a low-carbohydrate diet (LC) and a low-fat diet (LF) on bile mucin concentration and composition of gallbladder bile in six clinically healthy beagle dogs. After feeding of both diets, the bile mucin concentration was significantly decreased. In addition, there were significant decreases in the concentrations of taurochenodeoxycholic acid in bile, which is considered to promote mucin secretion, after feeding of both diets. The present study suggested that the proportions of carbohydrate and fat in diet affect the composition of gallbladder bile in dogs.

Citing Articles

Comprehensive gene expression analysis in gallbladder mucosal epithelial cells of dogs with gallbladder mucocele.

Nagao I, Motegi T, Goto-Koshino Y, Tsuboi M, Takahashi N, Chambers J J Vet Intern Med. 2024; 38(6):3031-3037.

PMID: 39529599 PMC: 11586547. DOI: 10.1111/jvim.17157.

Quantitative bile acid profiling in healthy adult dogs and pups from serum, plasma, urine, and feces using LC-MS/MS.

Karakus E, Proksch A, Moritz A, Geyer J Front Vet Sci. 2024; 11:1380920.

PMID: 38948668 PMC: 11211631. DOI: 10.3389/fvets.2024.1380920.

Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis.

Zhao Z, Yang Y, Wu S, Yao D Biomolecules. 2024; 14(6).

PMID: 38927079 PMC: 11201413. DOI: 10.3390/biom14060676.

References

Cook A, Jambhekar A, Dylewski A . Gallbladder Sludge in Dogs: Ultrasonographic and Clinical Findings in 200 Patients. J Am Anim Hosp Assoc. 2016; 52(3):125-31. DOI: 10.5326/JAAHA-MS-6282. View

Sutor D, Wilkie L, Jackson M . Ionised calcium in pathological human bile. J Clin Pathol. 1980; 33(1):86-8. PMC: 1145987. DOI: 10.1136/jcp.33.1.86. View

Kakimoto T, Kanemoto H, Fukushima K, Ohno K, Tsujimoto H . Effect of a high-fat-high-cholesterol diet on gallbladder bile acid composition and gallbladder motility in dogs. Am J Vet Res. 2017; 78(12):1406-1413. DOI: 10.2460/ajvr.78.12.1406. View

Kuver R, Lee S . Calcium binding to biliary mucins is dependent on sodium ion concentration: relevance to cystic fibrosis. Biochem Biophys Res Commun. 2004; 314(2):330-4. DOI: 10.1016/j.bbrc.2003.12.088. View

Kirpensteijn J, Fingland R, Ulrich T, Sikkema D, Allen S . Cholelithiasis in dogs: 29 cases (1980-1990). J Am Vet Med Assoc. 1993; 202(7):1137-42. View

Klinkspoor J, Kuver R, Savard C, Oda D, Azzouz H, Tytgat G . Model bile and bile salts accelerate mucin secretion by cultured dog gallbladder epithelial cells. Gastroenterology. 1995; 109(1):264-74. DOI: 10.1016/0016-5085(95)90293-7. View

Vaz F, Ferdinandusse S . Bile acid analysis in human disorders of bile acid biosynthesis. Mol Aspects Med. 2017; 56:10-24. DOI: 10.1016/j.mam.2017.03.003. View

Vilkin A, Nudelman I, Morgenstern S, Geller A, Bar Dayan Y, Levi Z . Gallbladder inflammation is associated with increase in mucin expression and pigmented stone formation. Dig Dis Sci. 2007; 52(7):1613-20. DOI: 10.1007/s10620-006-9162-9. View

Englert Jr E, Harman C, Freston J, Straight R, Wales Jr E . Studies on the pathogenesis of diet-induced dog gallstones. Am J Dig Dis. 1977; 22(4):305-14. DOI: 10.1007/BF01072187. View

10.

Park Y, Kim D, Lee J, Kim Y, Jeong Y, Lee K . Association between diet and gallstones of cholesterol and pigment among patients with cholecystectomy: a case-control study in Korea. J Health Popul Nutr. 2017; 36(1):39. PMC: 5701373. DOI: 10.1186/s41043-017-0116-y. View

11.

DeMonaco S, Grant D, Larson M, Panciera D, Leib M . Spontaneous Course of Biliary Sludge Over 12 Months in Dogs with Ultrasonographically Identified Biliary Sludge. J Vet Intern Med. 2016; 30(3):771-8. PMC: 4913576. DOI: 10.1111/jvim.13929. View

12.

Mizutani S, Torisu S, Kaneko Y, Yamamoto S, Fujimoto S, Ong B . Retrospective analysis of canine gallbladder contents in biliary sludge and gallbladder mucoceles. J Vet Med Sci. 2016; 79(2):366-374. PMC: 5326943. DOI: 10.1292/jvms.16-0562. View

13.

Fan L, Joseph J, Durairaj P, Parr M, Bureik M . Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1. Biol Chem. 2018; 400(5):625-628. DOI: 10.1515/hsz-2018-0379. View

14.

Lee Y, Song D, Kim J, Choi C . Effect of cholestyramine on the formation of pigment gallstone in high carbohydrate diet-fed hamsters. J Korean Med Sci. 1996; 11(5):397-401. PMC: 3054179. DOI: 10.3346/jkms.1996.11.5.397. View

15.

Washizu T, Ishida T, Washizu M, Tomoda I, Kaneko J . Changes in bile acid composition of serum and gallbladder bile in bile duct ligated dogs. J Vet Med Sci. 1994; 56(2):299-303. DOI: 10.1292/jvms.56.299. View

16.

Center S . Diseases of the gallbladder and biliary tree. Vet Clin North Am Small Anim Pract. 2009; 39(3):543-98. DOI: 10.1016/j.cvsm.2009.01.004. View

17.

Shiffman M, Sugerman H, KELLUM J, Moore E . Changes in gallbladder bile composition following gallstone formation and weight reduction. Gastroenterology. 1992; 103(1):214-21. DOI: 10.1016/0016-5085(92)91115-k. View

18.

Besso J, Wrigley R, Gliatto J, Webster C . Ultrasonographic appearance and clinical findings in 14 dogs with gallbladder mucocele. Vet Radiol Ultrasound. 2000; 41(3):261-71. DOI: 10.1111/j.1740-8261.2000.tb01489.x. View

19.

Kesimer M, Cullen J, Cao R, Radicioni G, Mathews K, Seiler G . Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs. PLoS One. 2015; 10(9):e0138988. PMC: 4586375. DOI: 10.1371/journal.pone.0138988. View

20.

Abedin M, Strichartz S, Festekdjian S, Roslyn J . Increased biliary calcium in cholesterol and pigment gallstone disease: the role of altered bile acid composition. Lipids. 1989; 24(7):572-8. DOI: 10.1007/BF02535071. View