Cord Blood IgE and Month of Birth

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1987 May 1

PMID 3606180

Citations 4

Authors

J Kimpen

H Callaert

P Embrechts

E Bosmans

Affiliations

Soon will be listed here.

Abstract

If cord blood IgE is used to detect those predisposed to become allergic it is important to define appropriately the normal values for this measurement. A commonly cited cut off point is 1.0 IU/ml. We analysed 5353 cord blood samples for IgE by means of an enzyme linked immunosorbent assay. Descriptive statistics of the distribution curve of cord blood IgE concentrations showed that most normal values were well below the cut off value of 1.0 IU/ml and that most abnormal values were in the neighbourhood of 1.0 IU/ml. It seems advantageous, therefore, to lower the cut off value for cord blood IgE. When cord blood IgE was analysed according to the child's month of birth a significantly uneven distribution of abnormal cases of cord blood IgE concentrations over the year was found. The occurrence of an abnormal cord blood IgE concentration showed a significant cyclic trend, with a peak near the end of April and a trough in late October.

Citing Articles

Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns.

Hernandez E, Barraza-Villarreal A, Escamilla-Nunez M, Hernandez-Cadena L, Sly P, Neufeld L Allergy Asthma Proc. 2013; 34(5):e27-34.

PMID: 23998234 PMC: 3973815. DOI: 10.2500/aap.2013.34.3688.

Effect of maternal lifestyle on cord blood IgE factor.

Shirakawa T, Morimoto K, Sasaki S, Taniguchi K, Motonaga M, Akahori W Eur J Epidemiol. 1997; 13(4):395-402.

PMID: 9258545 DOI: 10.1023/a:1007361013917.

Prospective study of the atopy preventive effect of maternal avoidance of milk and eggs during pregnancy and lactation.

Herrmann M, Dannemann A, Gruters A, Radisch B, Dudenhausen J, Bergmann R Eur J Pediatr. 1996; 155(9):770-4.

PMID: 8874109 DOI: 10.1007/BF02002904.

Food and drug reactions, wheezing, and eczema in preterm infants.

Lucas A, Brooke O, Cole T, Morley R, Bamford M Arch Dis Child. 1990; 65(4):411-5.

PMID: 2189368 PMC: 1792193. DOI: 10.1136/adc.65.4.411.

References

Engvall E, Perlmann P . Enzyme-linked immunosorbent assay (ELISA). Quantitative assay of immunoglobulin G. Immunochemistry. 1971; 8(9):871-4. DOI: 10.1016/0019-2791(71)90454-x. View

BJORKSTEN F, Suoniemi I . Dependence of immediate hypersensitivity on the month of birth. Clin Allergy. 1976; 6(2):165-71. DOI: 10.1111/j.1365-2222.1976.tb01894.x. View

Soothill J, Stokes C, Turner M, NORMAN A, Taylor B . Predisposing factors and the development of reaginic allergy in infancy. Clin Allergy. 1976; 6(4):305-19. DOI: 10.1111/j.1365-2222.1976.tb01911.x. View

Smith J, Springett V . Atopic disease and month of birth. Clin Allergy. 1979; 9(2):153-7. DOI: 10.1111/j.1365-2222.1979.tb01536.x. View

Saarinen U, Kajosaari M, Backman A, Siimes M . Prolonged breast-feeding as prophylaxis for atopic disease. Lancet. 1979; 2(8135):163-6. DOI: 10.1016/s0140-6736(79)91432-6. View

Michel F, Bousquet J, Greillier P, Coulomb Y . Comparison of cord blood immunoglobulin E concentrations and maternal allergy for the prediction of atopic diseases in infancy. J Allergy Clin Immunol. 1980; 65(6):422-30. DOI: 10.1016/0091-6749(80)90234-1. View

Croner S, Kjellman N, Eriksson B, Roth A . IgE screening in 1701 newborn infants and the development of atopic disease during infancy. Arch Dis Child. 1982; 57(5):364-8. PMC: 1627557. DOI: 10.1136/adc.57.5.364. View

Bayne N, Mathews K . Determination of total IgE by ELISA in tubes and plates compared with PRIST. Clin Biochem. 1982; 15(3):167-9. DOI: 10.1016/s0009-9120(82)90647-6. View

Kjellman N . Prediction and prevention of atopic allergy. Allergy. 1982; 37(7):463-73. DOI: 10.1111/j.1398-9995.1982.tb02329.x. View

10.

Duchateau J, Casimir G . Neonatal serum IgE concentration as predictor of atopy. Lancet. 1983; 1(8321):413-4. DOI: 10.1016/s0140-6736(83)91524-6. View

11.

Leclercq-Foucart J . [Prediction and prevention of allergy in infants and young children]. Rev Med Liege. 1983; 38(9):381-94. View

12.

BUSINCO L, Marchetti F, Pellegrini G, Cantani A, Perlini R . Prevention of atopic disease in "at-risk newborns" by prolonged breast-feeding. Ann Allergy. 1983; 51(2 Pt 2):296-9. View

13.

BUSINCO L, Marchetti F, Pellegrini G, Perlini R . Predictive value of cord blood IgE levels in 'at-risk' newborn babies and influence of type of feeding. Clin Allergy. 1983; 13(6):503-8. DOI: 10.1111/j.1365-2222.1983.tb02631.x. View

14.

BUSINCO L, Cantani A . Prevention of atopy--current concepts and personal experience. Clin Rev Allergy. 1984; 2(2):107-23. PMC: 7091011. DOI: 10.1007/BF02991060. View

15.

Kjellman N, Croner S . Cord blood IgE determination for allergy prediction--a follow-up to seven years of age in 1,651 children. Ann Allergy. 1984; 53(2):167-71. View

16.

David T, Beards S . Asthma and the month of birth. Clin Allergy. 1985; 15(4):391-5. DOI: 10.1111/j.1365-2222.1985.tb03008.x. View

17.

Chandra R, Puri S, Cheema P . Predictive value of cord blood IgE in the development of atopic disease and role of breast-feeding in its prevention. Clin Allergy. 1985; 15(6):517-22. DOI: 10.1111/j.1365-2222.1985.tb02304.x. View

18.

Croner S, Kjellman N . Predictors of atopic disease: cord blood IgE and month of birth. Allergy. 1986; 41(1):68-70. DOI: 10.1111/j.1398-9995.1986.tb00277.x. View