Progress in Preclinical Studies of Macrophage Autophagy in the Regulation of ALI/ARDS

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Sep 5

PMID 36059534

Authors

Chang Liu

Kun Xiao

Lixin Xie

Affiliations

Soon will be listed here.

Abstract

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with high morbidity and mortality that poses a major challenge in critical care medicine. The development of ALI/ARDS involves excessive inflammatory response, and macrophage autophagy plays an important role in regulating the inflammatory response in ALI/ARDS. In this paper, we review the effects of autophagy in regulating macrophage function, discuss the roles of macrophage autophagy in ALI/ARDS, and highlight drugs and other interventions that can modulate macrophage autophagy in ALI/ARDS to improve the understanding of the mechanism of macrophage autophagy in ALI/ARDS and provide new ideas and further research directions for the treatment of ALI/ARDS.

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