The Relationship Between Myodural Bridges, Hyperplasia of the Suboccipital Musculature, and Intracranial Pressure

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2022 Sep 2

PMID 36054096

Authors

Chan Li

Chen Yue

Zhao-Chang Liu

Jin Gong

Xiao-Song Wei

Heng Yang

Campbell Gilmore

Sheng-Bo Yu

Gary D Hack

Hong-Jin Sui

Affiliations

Soon will be listed here.

Abstract

During mammalian evolution, the Myodural Bridges (MDB) have been shown to be highly conserved anatomical structures. However, the putative physiological function of these structures remains unclear. The MDB functionally connects the suboccipital musculature to the cervical spinal dura mater, while passing through the posterior atlanto-occipital and atlanto-axial interspaces. MDB transmits the tensile forces generated by the suboccipital muscles to the cervical dura mater. Moreover, head movements have been shown to be an important contributor to human CSF circulation. In the present study, a 16-week administration of a Myostatin-specific inhibitor, ACE-031, was injected into the suboccipital musculature of rats to establish an experimental animal model of hyperplasia of the suboccipital musculature. Using an optic fiber pressure measurement instrument, the present authors observed a significant increase in intracranial pressure (ICP) while utilizing the hyperplasia model. In contrast, surgically severing the MDB connections resulted in a significant decrease in intracranial pressure. Thus, these results indicated that muscular activation of the MDB may affect CSF circulation, suggesting a potential functional role of the MDB, and providing a new research perspective on CSF dynamics.

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References

Xu Q, Yu S, Zheng N, Yuan X, Chi Y, Liu C . Head movement, an important contributor to human cerebrospinal fluid circulation. Sci Rep. 2016; 6:31787. PMC: 4990938. DOI: 10.1038/srep31787. View

Zheng N, Yuan X, Chi Y, Liu P, Wang B, Sui J . The universal existence of myodural bridge in mammals: an indication of a necessary function. Sci Rep. 2017; 7(1):8248. PMC: 5557938. DOI: 10.1038/s41598-017-06863-z. View

Fardon D, Williams A, Dohring E, Murtagh F, Gabriel Rothman S, Sze G . Lumbar disc nomenclature: version 2.0: Recommendations of the combined task forces of the North American Spine Society, the American Society of Spine Radiology and the American Society of Neuroradiology. Spine J. 2014; 14(11):2525-45. DOI: 10.1016/j.spinee.2014.04.022. View

Alperin N, Hushek S, Lee S, Sivaramakrishnan A, Lichtor T . MRI study of cerebral blood flow and CSF flow dynamics in an upright posture: the effect of posture on the intracranial compliance and pressure. Acta Neurochir Suppl. 2006; 95:177-81. DOI: 10.1007/3-211-32318-x_38. View

Stitt T, Drujan D, Clarke B, Panaro F, Timofeyva Y, Kline W . The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell. 2004; 14(3):395-403. DOI: 10.1016/s1097-2765(04)00211-4. View

Shadwick R, Gosline J . Arterial Windkessels in marine mammals. Symp Soc Exp Biol. 1995; 49:243-52. View

Goldbogen J, Cade D, Calambokidis J, Czapanskiy M, Fahlbusch J, Friedlaender A . Extreme bradycardia and tachycardia in the world's largest animal. Proc Natl Acad Sci U S A. 2019; 116(50):25329-25332. PMC: 6911174. DOI: 10.1073/pnas.1914273116. View

Friese S, Hamhaber U, Erb M, Kueker W, Klose U . The influence of pulse and respiration on spinal cerebrospinal fluid pulsation. Invest Radiol. 2004; 39(2):120-30. DOI: 10.1097/01.rli.0000112089.66448.bd. View

Alix M, Bates D . A proposed etiology of cervicogenic headache: the neurophysiologic basis and anatomic relationship between the dura mater and the rectus posterior capitis minor muscle. J Manipulative Physiol Ther. 1999; 22(8):534-9. DOI: 10.1016/S0161-4754(99)70006-0. View

10.

Zheng N, Yuan X, Li Y, Chi Y, Gao H, Zhao X . Definition of the to be named ligament and vertebrodural ligament and their possible effects on the circulation of CSF. PLoS One. 2014; 9(8):e103451. PMC: 4118883. DOI: 10.1371/journal.pone.0103451. View

11.

Luo J, Sobkiw C, Hirshman M, Logsdon M, Li T, Goodyear L . Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. Cell Metab. 2006; 3(5):355-66. DOI: 10.1016/j.cmet.2006.04.003. View

12.

Zhang J, Tang W, Zhang Z, Luan B, Yu S, Sui H . Connection of the Posterior Occipital Muscle and Dura Mater of the Siamese Crocodile. Anat Rec (Hoboken). 2016; 299(10):1402-8. DOI: 10.1002/ar.23445. View

13.

Pontell M, Scali F, Enix D, Battaglia P, Marshall E . Histological examination of the human obliquus capitis inferior myodural bridge. Ann Anat. 2013; 195(6):522-6. DOI: 10.1016/j.aanat.2013.04.013. View

14.

Liu P, Li C, Zheng N, Yuan X, Zhou Y, Chun P . The myodural bridges' existence in the sperm whale. PLoS One. 2018; 13(7):e0200260. PMC: 6037366. DOI: 10.1371/journal.pone.0200260. View

15.

Gonzalez-Cadavid N, TAYLOR W, Yarasheski K, Sinha-Hikim I, Ma K, Ezzat S . Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci U S A. 1998; 95(25):14938-43. PMC: 24554. DOI: 10.1073/pnas.95.25.14938. View

16.

Scali F, Pontell M, Enix D, Marshall E . Histological analysis of the rectus capitis posterior major's myodural bridge. Spine J. 2013; 13(5):558-63. DOI: 10.1016/j.spinee.2013.01.015. View

17.

Dean N, Mitchell B . Anatomic relation between the nuchal ligament (ligamentum nuchae) and the spinal dura mater in the craniocervical region. Clin Anat. 2002; 15(3):182-5. DOI: 10.1002/ca.10001. View

18.

Liu P, Li C, Zheng N, Xu Q, Yu S, Sui H . The myodural bridge existing in the Nephocaena phocaenoides. PLoS One. 2017; 12(3):e0173630. PMC: 5344499. DOI: 10.1371/journal.pone.0173630. View

19.

Wadhwani S, Loughenbury P, Soames R . The anterior dural (Hofmann) ligaments. Spine (Phila Pa 1976). 2004; 29(6):623-7. DOI: 10.1097/01.brs.0000115129.59484.24. View

20.

Newell R . The spinal epidural space. Clin Anat. 1999; 12(5):375-9. DOI: 10.1002/(SICI)1098-2353(1999)12:5<375::AID-CA7>3.0.CO;2-6. View