Association Between Dyslipidaemia and the Risk of Hyperuricaemia: a Six-year Longitudinal Cohort Study of Elderly Individuals in China

Overview

Journal Ann Med

Publisher Informa Healthcare

Specialty General Medicine

Date 2022 Sep 2

PMID 36053052

Authors

Ying Xu

Haoyu Dong

Boya Zhang

Jiayu Zhang

QingHua Ma

Hongpeng Sun

Affiliations

Soon will be listed here.

Abstract

Background: Despite abundant evidence linking dyslipidaemia to an increased risk of hyperuricaemia, the exact association between each component of dyslipidaemia and hyperuricaemia remains controversial. Thus, the objective of this research was to examine the correlation between dyslipidaemia and its components, as well as hyperuricaemia in Chinese people over the age of 60.

Methods: In this study, 4018 participants over 60 years without hyperuricaemia were investigated from 2014 to 2020. The association between each dyslipidaemia component and hyperuricaemia was evaluated employing Cox proportional hazards models. This research conducted further stratified and sensitivity analyses to assess the potential relationship.

Results: A total of 1155 participants suffered from hyperuricaemia (28.75%) at the time of the 6-year follow-up survey. In multivariable-adjusted analyses, compared to participants with normal lipid levels, those with dyslipidaemia had 1.28 times the risk (95% confidence interval 1.12 to 1.47) of experiencing hyperuricaemia. The hazard ratios (HR) (95% CI) comparing high TC, high TG, high LDL-C, and low HDL-C of dyslipidaemia with the regular group were 0.99 (0.72 to 1.37), 1.30 (1.07 to 1.57), 1.02 (0.70 to 1.50), and 1.20 (1.00 to 1.44), respectively. There was a nonlinear dose-response between TG, HDL-C, and serum uric acid (SUA).

Conclusions: Dyslipidaemia and its two distinct types, high TG and low HDL-C, increased hyperuricaemia incidence in this prospective cohort. Further research should be undertaken to investigate the possible reverse causality between different components of dyslipidaemia and hyperuricaemia.

Citing Articles

Associations of Plasma Lipidomic Profiles with Uric Acid and Hyperuricemia Risk in Middle-Aged and Elderly Chinese.

Kang W, Xu X, Yang X, Wu Q, Li S, Gao K Phenomics. 2024; 4(4):352-364.

PMID: 39583309 PMC: 11584823. DOI: 10.1007/s43657-024-00157-x.

Exploring the associations and potential mediators between lipid biomarkers and the risk of developing gout: NHANES 2007-2018.

Huang Y, Li Y, Wu Z, Liang Y, He J Lipids Health Dis. 2024; 23(1):363.

PMID: 39511685 PMC: 11542235. DOI: 10.1186/s12944-024-02346-z.

Exploring the Relationship Between Different Obesity Metabolism Indices and Hyperuricemia in Patients with Hypertension and Coronary Heart Disease.

Li Y, Yi S, Jiang W, Gong M Diabetes Metab Syndr Obes. 2024; 17:3817-3832.

PMID: 39440026 PMC: 11495196. DOI: 10.2147/DMSO.S491255.

Gender-Specific Differences in Prevalence and Association of Cardio-Metabolic Parameters and Hyperuricemia: A Population-Based Cross-Sectional Study, Nakhon Nayok, Thailand.

Suwanchatchai C, Khuancharee K, Tanunyutthawongse C, Wannaiampikul S, Haetanurak P Iran J Public Health. 2024; 53(6):1361-1371.

PMID: 39430161 PMC: 11488558.

The Association of Dietary Diversity with Hyperuricemia among Community Inhabitants in Shanghai, China: A Prospective Research.

Xu X, He M, Zhao G, Liu X, Liu X, Xu H Nutrients. 2024; 16(17).

PMID: 39275283 PMC: 11397405. DOI: 10.3390/nu16172968.

References

Stelmach M, Wasilewska N, Wicklund-Liland L, Wasilewska A . Blood lipid profile and BMI-Z-score in adolescents with hyperuricemia. Ir J Med Sci. 2014; 184(2):463-8. DOI: 10.1007/s11845-014-1146-8. View

Shankar A, Klein R, Klein B, Nieto F . The association between serum uric acid level and long-term incidence of hypertension: Population-based cohort study. J Hum Hypertens. 2006; 20(12):937-45. DOI: 10.1038/sj.jhh.1002095. View

Engin A . Adiponectin-Resistance in Obesity. Adv Exp Med Biol. 2017; 960:415-441. DOI: 10.1007/978-3-319-48382-5_18. View

Jia W, Weng J, Zhu D, Ji L, Lu J, Zhou Z . Standards of medical care for type 2 diabetes in China 2019. Diabetes Metab Res Rev. 2019; 35(6):e3158. DOI: 10.1002/dmrr.3158. View

Ali N, Rahman S, Islam S, Haque T, Molla N, Sumon A . The relationship between serum uric acid and lipid profile in Bangladeshi adults. BMC Cardiovasc Disord. 2019; 19(1):42. PMC: 6385393. DOI: 10.1186/s12872-019-1026-2. View

Zhu Y, Pandya B, Choi H . Prevalence of gout and hyperuricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008. Arthritis Rheum. 2011; 63(10):3136-41. DOI: 10.1002/art.30520. View

Zhang J, Song P, Zhao L, Sun Y, Yu K, Yin J . Malnutrition in Relation with Dietary, Geographical, and Socioeconomic Factors among Older Chinese. Biomed Environ Sci. 2021; 34(5):337-347. DOI: 10.3967/bes2021.045. View

Wang R, Tang Z, Sun F, Diao L . [Prevalence of hyperuricemia in the elderly in 7 areas of China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2018; 39(3):286-288. DOI: 10.3760/cma.j.issn.0254-6450.2018.03.007. View

Liang J, Jiang Y, Huang Y, Song W, Li X, Huang Y . The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study. Lipids Health Dis. 2020; 19(1):31. PMC: 7053114. DOI: 10.1186/s12944-020-1197-y. View

10.

Wang W, Ren H, Tian Q, Tang C, Meng W . Effects of Occupational Stress on Blood Lipids, Blood Sugar and Immune Function of Doctors. Iran J Public Health. 2019; 48(5):825-833. PMC: 6717409. View

11.

Wei F, Sun N, Cai C, Feng S, Tian J, Shi W . Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study. J Transl Med. 2016; 14(1):110. PMC: 4851787. DOI: 10.1186/s12967-016-0866-0. View

12.

Han T, Meng X, Shan R, Zi T, Li Y, Ma H . Temporal relationship between hyperuricemia and obesity, and its association with future risk of type 2 diabetes. Int J Obes (Lond). 2018; 42(7):1336-1344. DOI: 10.1038/s41366-018-0074-5. View

13.

Qiu L, Cheng X, Wu J, Liu J, Xu T, Ding H . Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces. BMC Public Health. 2013; 13:664. PMC: 3722003. DOI: 10.1186/1471-2458-13-664. View

14.

Nicholls S, Nelson A . HDL and cardiovascular disease. Pathology. 2019; 51(2):142-147. DOI: 10.1016/j.pathol.2018.10.017. View

15.

Aihemaitijiang S, Zhang Y, Zhang L, Yang J, Ye C, Halimulati M . The Association between Purine-Rich Food Intake and Hyperuricemia: A Cross-Sectional Study in Chinese Adult Residents. Nutrients. 2020; 12(12). PMC: 7765492. DOI: 10.3390/nu12123835. View

16.

Lu W, Song K, Wang Y, Zhang Q, Li W, Jiao H . Relationship between serum uric acid and metabolic syndrome: an analysis by structural equation modeling. J Clin Lipidol. 2012; 6(2):159-67. DOI: 10.1016/j.jacl.2011.11.006. View

17.

Nakanishi N, Tatara K, Nakamura K, Suzuki K . Risk factors for the incidence of hyperuricaemia: a 6-year longitudinal study of middle-aged Japanese men. Int J Epidemiol. 1999; 28(5):888-93. DOI: 10.1093/ije/28.5.888. View

18.

Zhao Y, Liu X, Mao Z, Hou J, Huo W, Wang C . Relationship between multiple healthy lifestyles and serum lipids among adults in rural China: A population-based cross-sectional study. Prev Med. 2020; 138:106158. DOI: 10.1016/j.ypmed.2020.106158. View

19.

Akande T, Adeleye J, Kadiri S . Insulin resistance in Nigerians with essential hypertension. Afr Health Sci. 2013; 13(3):655-60. PMC: 3824445. DOI: 10.4314/ahs.v13i3.19. View

20.

Wang Z, Chen Z, Zhang L, Wang X, Hao G, Zhang Z . Status of Hypertension in China: Results From the China Hypertension Survey, 2012-2015. Circulation. 2018; 137(22):2344-2356. DOI: 10.1161/CIRCULATIONAHA.117.032380. View