Association of Vitamin B12/ferritin Deficiency in Cancer Patients with Methylomic Changes at Promotors of methylcytosine Dioxygenases

Overview

Journal Biomark Med

Specialties Biochemistry
General Medicine

Date 2022 Sep 2

PMID 36052661

Authors

Khaled A Elawdan

Sabah Farouk

Salah Aref

Hamada Shoaib

Mohamed A El-Razik

Nasser H Abbas

Mohamed Younis

Abeer A Alshambky

Hany Khalil

Affiliations

Soon will be listed here.

Abstract

To investigate potential DNA methylation in methylcytosine dioxygenases and correlation of genes with vitamin B12/ferritin levels in cancer patients. 200 blood samples were obtained from both cancer patients and healthy individuals. The expression of , and was increased in patients with low vitamin B12 and ferritin levels, while the expression of , and significantly decreased. DNA methylation analysis in patients with deficient vitamin B12/ferritin levels showed methylomic changes within the location 318/CG and 385/CG in the promoter region of and , respectively. Vitamin B12/ferritin deficiency contributes to DNA methylation progress in cancer patients.

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