How Efficacious is the Combination of Substitute Bone Graft with Autogenous Bone Graft in Comparison with Substitute Bone Graft Alone in the Horizontal Bone Gain? A Systematic Review and Meta-analysis

Overview

Journal J Clin Exp Dent

Specialty Dentistry

Date 2022 Sep 1

PMID 36046167

Authors

Jonathan Meza-Mauricio

Camila-Pinheiro Furquim

Leonardo-Delfino Dos Reis

Marlon-Marx-Hilariano Maximiano

Gerardo Mendoza-Azpur

Francisco-Wilker-Mustafa-Gomes Muniz

Giulio Rasperini

Marcelo Faveri

Affiliations

Soon will be listed here.

Abstract

Background: A systematic review (SR) was conducted to answer the following focused question based on PICO strategy: In patients who were submitted to horizontal guided bone regeneration, "how efficacious is the combination of substitute bone graft with autogenous bone graft in comparison with substitute bone graft alone, in terms of bone gain?"

Material And Methods: MEDLINE (PubMed), Scopus, Embase, Web of Science databases were searched, and hand searches were made up to June 2021, to find randomized clinical trials comparing the clinical effects of autogenous bone graft + substitute bone graft versus substitute bone graft alone in the treatment of horizontal guided bone regeneration.

Results: Four trials representing 109 individuals were included. All studies included in this SR used allogeneic bone graft. The meta-analysis did not show any statistically significant difference between the groups, for horizontal bone gain at a distance of 0 mm (MD: -0.46; 95%CI: -1.03 - 0.11) or at a distance of 4 to 5 mm from the top of the crestal alveolar ridge (MD: 0.17; 95%CI: -1.08 - 1.42).

Conclusions: Within limitations of this systematic review, it was concluded that the addition of autogenous bone graft to the allogeneic bone graft did not significantly increase the quantity of regenerated bone. Bone graft, bone regeneration, allograft.

Citing Articles

Allogeneic versus autogenous shell technique augmentation procedures: a prospective-observational clinical trial comparing surgical time and complication rates.

Tunkel J, Hoffmann F, Schmelcher Y, Kloss-Brandstatter A, Kammerer P Int J Implant Dent. 2023; 9(1):52.

PMID: 38117445 PMC: 10733239. DOI: 10.1186/s40729-023-00505-y.

References

Starch-Jensen T, Becktor J . Maxillary Alveolar Ridge Expansion with Split-Crest Technique Compared with Lateral Ridge Augmentation with Autogenous Bone Block Graft: a Systematic Review. J Oral Maxillofac Res. 2020; 10(4):e2. PMC: 7012616. DOI: 10.5037/jomr.2019.10402. View

Urban I, Nagursky H, Lozada J, Nagy K . Horizontal ridge augmentation with a collagen membrane and a combination of particulated autogenous bone and anorganic bovine bone-derived mineral: a prospective case series in 25 patients. Int J Periodontics Restorative Dent. 2013; 33(3):299-307. DOI: 10.11607/prd.1407. View

Dasmah A, Thor A, Ekestubbe A, Sennerby L, Rasmusson L . Particulate vs. block bone grafts: three-dimensional changes in graft volume after reconstruction of the atrophic maxilla, a 2-year radiographic follow-up. J Craniomaxillofac Surg. 2011; 40(8):654-9. DOI: 10.1016/j.jcms.2011.10.032. View

Simion M, Fontana F, Rasperini G, Maiorana C . Vertical ridge augmentation by expanded-polytetrafluoroethylene membrane and a combination of intraoral autogenous bone graft and deproteinized anorganic bovine bone (Bio Oss). Clin Oral Implants Res. 2007; 18(5):620-9. DOI: 10.1111/j.1600-0501.2007.01389.x. View

Guyatt G, Oxman A, Schunemann H, Tugwell P, Knottnerus A . GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology. J Clin Epidemiol. 2010; 64(4):380-2. DOI: 10.1016/j.jclinepi.2010.09.011. View

Mordenfeld A, Aludden H, Starch-Jensen T . Lateral ridge augmentation with two different ratios of deproteinized bovine bone and autogenous bone: A 2-year follow-up of a randomized and controlled trial. Clin Implant Dent Relat Res. 2017; 19(5):884-894. DOI: 10.1111/cid.12512. View

Temmerman A, Cortellini S, Van Dessel J, De Greef A, Jacobs R, Dhondt R . Bovine-derived xenograft in combination with autogenous bone chips versus xenograft alone for the augmentation of bony dehiscences around oral implants: A randomized, controlled, split-mouth clinical trial. J Clin Periodontol. 2019; 47(1):110-119. DOI: 10.1111/jcpe.13209. View

Borges G, Novaes Jr A, Grisi M, Palioto D, Taba Jr M, Scombatti de Souza S . Acellular dermal matrix as a barrier in guided bone regeneration: a clinical, radiographic and histomorphometric study in dogs. Clin Oral Implants Res. 2009; 20(10):1105-15. DOI: 10.1111/j.1600-0501.2009.01731.x. View

Greenhalgh T, Peacock R . Effectiveness and efficiency of search methods in systematic reviews of complex evidence: audit of primary sources. BMJ. 2005; 331(7524):1064-5. PMC: 1283190. DOI: 10.1136/bmj.38636.593461.68. View

10.

Borie E, Fuentes R, Del Sol M, Oporto G, Engelke W . The influence of FDBA and autogenous bone particles on regeneration of calvaria defects in the rabbit: a pilot study. Ann Anat. 2011; 193(5):412-7. DOI: 10.1016/j.aanat.2011.06.003. View

11.

Jacotti M, Barausse C, Felice P . Posterior atrophic mandible rehabilitation with onlay allograft created with CAD-CAM procedure: a case report. Implant Dent. 2014; 23(1):22-8. DOI: 10.1097/ID.0000000000000023. View

12.

Araujo M, Lindhe J . Dimensional ridge alterations following tooth extraction. An experimental study in the dog. J Clin Periodontol. 2005; 32(2):212-8. DOI: 10.1111/j.1600-051X.2005.00642.x. View

13.

Couso-Queiruga E, Stuhr S, Tattan M, Chambrone L, Avila-Ortiz G . Post-extraction dimensional changes: A systematic review and meta-analysis. J Clin Periodontol. 2020; 48(1):126-144. DOI: 10.1111/jcpe.13390. View

14.

Schardt C, Adams M, Owens T, Keitz S, Fontelo P . Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med Inform Decis Mak. 2007; 7:16. PMC: 1904193. DOI: 10.1186/1472-6947-7-16. View

15.

Chavda S, Levin L . Human Studies of Vertical and Horizontal Alveolar Ridge Augmentation Comparing Different Types of Bone Graft Materials: A Systematic Review. J Oral Implantol. 2017; 44(1):74-84. DOI: 10.1563/aaid-joi-D-17-00053. View

16.

Janner S, Bosshardt D, Cochran D, Chappuis V, Huynh-Ba G, Jones A . The influence of collagen membrane and autogenous bone chips on bone augmentation in the anterior maxilla: a preclinical study. Clin Oral Implants Res. 2016; 28(11):1368-1380. DOI: 10.1111/clr.12996. View

17.

Silva F, Cortez A, Moreira R, Mazzonetto R . Complications of intraoral donor site for bone grafting prior to implant placement. Implant Dent. 2006; 15(4):420-6. DOI: 10.1097/01.id.0000246225.51298.67. View

18.

Carlsson G, Persson G . Morphologic changes of the mandible after extraction and wearing of dentures. A longitudinal, clinical, and x-ray cephalometric study covering 5 years. Odontol Revy. 1967; 18(1):27-54. View

19.

Mendoza-Azpur G, de la Fuente A, Chavez E, Valdivia E, Khouly I . Horizontal ridge augmentation with guided bone regeneration using particulate xenogenic bone substitutes with or without autogenous block grafts: A randomized controlled trial. Clin Implant Dent Relat Res. 2019; 21(4):521-530. DOI: 10.1111/cid.12740. View

20.

Meloni S, Jovanovic S, Urban I, Baldoni E, Pisano M, Tallarico M . Horizontal ridge augmentation using GBR with a native collagen membrane and 1:1 ratio of particulate xenograft and autologous bone: A 3-year after final loading prospective clinical study. Clin Implant Dent Relat Res. 2019; 21(4):669-677. DOI: 10.1111/cid.12808. View