Intestinal Cellular Heterogeneity and Disease Development Revealed by Single-cell Technology

Overview

Journal Cell Regen

Publisher Springer

Date 2022 Aug 31

PMID 36045190

Authors

Yalong Wang

Wanlu Song

Shicheng Yu

Yuan Liu

Ye-Guang Chen

Affiliations

Soon will be listed here.

Abstract

The intestinal epithelium is responsible for food digestion and nutrient absorption and plays a critical role in hormone secretion, microorganism defense, and immune response. These functions depend on the integral single-layered intestinal epithelium, which shows diversified cell constitution and rapid self-renewal and presents powerful regeneration plasticity after injury. Derailment of homeostasis of the intestine epithelium leads to the development of diseases, most commonly including enteritis and colorectal cancer. Therefore, it is important to understand the cellular characterization of the intestinal epithelium at the molecular level and the mechanisms underlying its homeostatic maintenance. Single-cell technologies allow us to gain molecular insights at the single-cell level. In this review, we summarize the single-cell RNA sequencing applications to understand intestinal cell characteristics, spatiotemporal evolution, and intestinal disease development.

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