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Blastomycosis Presenting With Acute Airway Obstruction From a Retropharyngeal Abscess and Complicated by Severe Hypokalemia During Posaconazole Therapy: A Case Report and Review of Literature

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Date 2022 Aug 31
PMID 36043181
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Abstract

We report a case of cervical blastomycosis with associated paravertebral involvement and severe spinal canal stenosis in a 48-year-old patient presenting with acute airway obstruction from a retropharyngeal abscess. Our case was also complicated by severe hypokalemia that developed during the blastomycosis treatment course with posaconazole and which improved after discontinuation and replacement therapy. After 12 months of blastomycosis-targeted therapy, our patient had complete resolution of clinical, laboratory, and radiological findings of blastomycosis.

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References
1.
Saccente M, Abernathy R, Pappas P, Shah H, Bradsher R . Vertebral blastomycosis with paravertebral abscess: report of eight cases and review of the literature. Clin Infect Dis. 1998; 26(2):413-8. DOI: 10.1086/clinids/26.2.413. View

2.
Davis M, Nguyen M, Gintjee T, Odermatt A, Young B, Thompson G . Management of posaconazole-induced pseudohyperaldosteronism. J Antimicrob Chemother. 2020; 75(12):3688-3693. DOI: 10.1093/jac/dkaa366. View

3.
Felton T, Troke P, Hope W . Tissue penetration of antifungal agents. Clin Microbiol Rev. 2014; 27(1):68-88. PMC: 3910906. DOI: 10.1128/CMR.00046-13. View

4.
Gehweiler J, CAPP M, CHICK E . Observations on the roentgen patterns in blastomycosis of bone. A review of cases from the Blastomycosis Cooperative Study of the Veterans Administration and Duke University Medical Center. Am J Roentgenol Radium Ther Nucl Med. 1970; 108(3):497-510. View

5.
Nokes S, ADAMETZ J, Gardner G, Beaton J . Radiological case of the month. Blastomycosis osteomyelitis with epidural and retropharyngeal abscess. J Ark Med Soc. 1995; 92(5):253-4. View