Intramodal Cortical Plastic Changes After Moderate Visual Impairment in Human Amblyopia

Overview

Journal iScience

Publisher Cell Press

Date 2022 Aug 29

PMID 36034215

Authors

Matin Mortazavi

Kiera Aigner

Jessica E Antono

Christina Gambacorta

Mor Nahum

Dennis M Levi

Julia Focker

Affiliations

Soon will be listed here.

Abstract

Early blindness results in alterations in the neural responses to auditory stimuli. Here we show that even moderately reduced vision in one eye early in life is sufficient to induce neural plastic changes in voice processing. We asked individuals with reduced visual acuity in one eye due to amblyopia to attend to vocal cues during electroencephalogram recording. We found enhanced frontal auditory responses at 125 ms-225 ms, which were correlated with reduced vision in the amblyopic eye, but not the fellow eye. Our results indicate intramodal reorganization, typically observed after congenital profound visual deprivation.

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