Diarrhoeagenic Isolated from Children with Acute Diarrhoea at Rakai Hospital, Southern Uganda

Overview

Journal Afr Health Sci

Date 2022 Aug 29

PMID 36032447

Authors

Fredrick Masiga

Edgar Kigozi

Christine Florence Najjuka

Henry Kajumbula

David Patrick Kateete

Affiliations

Soon will be listed here.

Abstract

Background: Diarrhoeagenic (DEC) is a leading cause of childhood diarrhoea. This study estimated the prevalence of DEC and DEC pathotypes among children with acute diarrhoea in Southern Uganda.

Methods: A cross-sectional study was conducted on 267 children less than 5 years with acute diarrhoea, admitted to Rakai General Hospital in Southern Uganda. Faecal samples were collected from the children and processed for isolation of . The presence of DEC and the distribution of DEC pathotypes were determined by polymerase chain reaction.

Results: A total of 102 (38.2%, 102/267) children had DEC of various pathotypes - enteroaggregative (EAEC) (14.2%); enteropathogenic E. coli (EPEC) (6.7%); enterotoxigenic (ETEC) (6%); enteroinvasive (EIEC) (7.5%); enterohemorrhagic (EHEC) (3%); and cell-detaching E. coli (CDEC) (0.75%). The difference in the overall prevalence of DEC was not significant regarding HIV but individually, EAEC and CDEC were associated with HIV-positive status while ETEC was associated with HIV-negative status.

Conclusions: DEC is prevalent in children with acute diarrhoea in Southern Uganda and its identification in children should be considered among strategies for combatting childhood diarrhoea in Africa.

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