Topography and Distribution of Adenosine A and Dopamine D Receptors in the Human Subthalamic Nucleus

Overview

Journal Front Neurosci

Date 2022 Aug 26

PMID 36017181

Authors

Aron Emmi

Angelo Antonini

Michele Sandre

Andrea Baldo

Martina Contran

Veronica Macchi

Diego Guidolin

Andrea Porzionato

Raffaele De Caro

Affiliations

Soon will be listed here.

Abstract

The human Subthalamic Nucleus (STh) is a diencephalic lens-shaped structure located ventrally to the thalamus and functionally implicated in the basal ganglia circuits. Despite recent efforts to characterize the neurochemical and functional anatomy of the STh, little to no information is available concerning the expression and distribution of receptors belonging to the dopaminergic and purinergic system in the human STh. Both systems are consistently implicated in basal ganglia physiology and pathology, especially in Parkinson's Disease, and represent important targets for the pharmacological treatment of movement disorders. Here, we investigate the topography and distribution of A adenosine and D dopamine receptors in the human basal ganglia and subthalamic nucleus. Our findings indicate a peculiar topographical distribution of the two receptors throughout the subthalamic nucleus, while colocalization between the receptors opens the possibility for the presence of AR- DR heterodimers within the dorsal and medial aspects of the structure. However, further investigation is required to confirm these findings.

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