Crosstalk Between Regulatory Non-coding RNAs and Oxidative Stress in Parkinson's Disease

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2022 Aug 26

PMID 36016854

Authors

Hantao Zhang

Xiaoyan Liu

Yi Liu

Junlin Liu

Xun Gong

Gang Li

Min Tang

Affiliations

Soon will be listed here.

Abstract

Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease, which imposes an ever-increasing burden on society. Many studies have indicated that oxidative stress may play an important role in Parkinson's disease through multiple processes related to dysfunction or loss of neurons. Besides, several subtypes of non-coding RNAs are found to be involved in this neurodegenerative disorder. However, the interplay between oxidative stress and regulatory non-coding RNAs in Parkinson's disease remains to be clarified. In this article, we comprehensively survey and overview the role of regulatory ncRNAs in combination with oxidative stress in Parkinson's disease. The interaction between them is also summarized. We aim to provide readers with a relatively novel insight into the pathogenesis of Parkinson's disease, which would contribute to the development of pre-clinical diagnosis and treatment.

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