The T350G Variation of Human Papillomavirus 16 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2022 Aug 26

PMID 36016346

Authors

Christine Kottaridi

Panagiota Resta

Danai Leventakou

Katerina Gioti

Ioannis Zygouras

Alina-Roxani Gouloumi

Georgios Sakagiannis

Khalid J Alzahrani

Maria S Venetikou

Fragkiski Anthouli-Anagnostopoulou

Apostolos Beloukas

Affiliations

Soon will be listed here.

Abstract

Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma strongly associated with high-risk human papillomavirus (HPV) of type 16. The genetic variability of HPV16 has been extensively studied in cervical cancer but there are very limited published data concerning the genetic variations of this HPV type in oropharyngeal cancer. In the present study, the genetic variations of HPV16 gene sequences originated from a small cohort of Greek patients diagnosed with oropharyngeal cancer were assessed. The vast majority of the sequences clustered within the European variant branch. The T350G variation was found to be the predominant one. This finding may indicate the need for further studies that could explain the possible impact of this variant in the pathomechanisms of oropharyngeal cancer.

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