» Articles » PMID: 36016256

SARS-CoV-2 Vaccine Uptake During Pregnancy in Regione Lombardia, Italy: A Population-Based Study of 122,942 Pregnant Women

Overview
Date 2022 Aug 26
PMID 36016256
Authors
Affiliations
Soon will be listed here.
Abstract

Italy has been one of the hardest hit countries in the European Union since the beginning of the SARS-CoV-2 pandemic, and Regione Lombardia (RL) has reported the largest number of cases in the country. This population-based retrospective study analyzed RL records of 122,942 pregnant women to describe SARS-CoV-2 vaccination uptake in the pregnant population, to compare pregnant women vaccine uptake vs. women of childbearing age and to evaluate the impact of vaccination status in pregnant women on admissions to intensive care units during 2021. Vaccination uptake according to citizenship and educational level and the comparison between pregnant and non-pregnant women was performed by Z test. A logistic regression was performed to compare age groups. Out of 122,942 pregnant women, 79.9% were vaccinated at the end of 2021. The vaccine uptake rate was significantly lower in pregnant versus non-pregnant women but increased after the issuing of official recommendations. Vaccine administration was significantly higher among pregnant women with Italian citizenship and with a high level of education in all trimesters. In conclusion, the role of official recommendations with explicit communication about the importance and safety of vaccination in pregnancy is critical to obtain trust and acceptance among pregnant women.

Citing Articles

COVID-19 Vaccination Acceptance During Pregnancy in Europe.

Tsiaousi I, Psarris A, Theodora M, Antsaklis P, Sindos M, Koutroumanis P Cureus. 2024; 16(7):e63562.

PMID: 39087190 PMC: 11289694. DOI: 10.7759/cureus.63562.


COVID-19 Vaccination Actual Uptake and Potential Inequalities Due to Socio-Demographic Characteristics: A Population-Based Study in the Umbria Region, Italy.

Primieri C, Chiavarini M, Giacchetta I, de Waure C, Bietta C Vaccines (Basel). 2023; 11(8).

PMID: 37631919 PMC: 10458483. DOI: 10.3390/vaccines11081351.


Immune Response and Transplacental Antibody Transfer in Pregnant Women after COVID-19 Vaccination.

Lubrano C, Mancon A, Anelli G, Gagliardi G, Corneo R, Bianchi M J Pers Med. 2023; 13(4).

PMID: 37109075 PMC: 10141882. DOI: 10.3390/jpm13040689.


Psychosocial Predictors of COVID-19 Vaccine Uptake among Pregnant Women: A Cross-Sectional Study in Greece.

Galanis P, Vraka I, Katsiroumpa A, Siskou O, Konstantakopoulou O, Zogaki E Vaccines (Basel). 2023; 11(2).

PMID: 36851147 PMC: 9967309. DOI: 10.3390/vaccines11020269.


The State of Play on COVID-19 Vaccination in Pregnant and Breastfeeding Women: Recommendations, Legal Protection, Ethical Issues and Controversies in Italy.

Scendoni R, Fedeli P, Cingolani M Healthcare (Basel). 2023; 11(3).

PMID: 36766904 PMC: 9913898. DOI: 10.3390/healthcare11030328.


References
1.
Gill L, Jones C . Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies in Neonatal Cord Blood After Vaccination in Pregnancy. Obstet Gynecol. 2021; 137(5):894-896. DOI: 10.1097/AOG.0000000000004367. View

2.
Stock S, Carruthers J, Calvert C, Denny C, Donaghy J, Goulding A . SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland. Nat Med. 2022; 28(3):504-512. PMC: 8938271. DOI: 10.1038/s41591-021-01666-2. View

3.
Gray K, Bordt E, Atyeo C, DeRiso E, Akinwunmi B, Young N . Coronavirus disease 2019 vaccine response in pregnant and lactating women: a cohort study. Am J Obstet Gynecol. 2021; 225(3):303.e1-303.e17. PMC: 7997025. DOI: 10.1016/j.ajog.2021.03.023. View

4.
Levy A, Singh S, Riley L, Prabhu M . Acceptance of COVID-19 vaccination in pregnancy: a survey study. Am J Obstet Gynecol MFM. 2021; 3(5):100399. PMC: 8129996. DOI: 10.1016/j.ajogmf.2021.100399. View

5.
Luxi N, Giovanazzi A, Capuano A, Crisafulli S, Cutroneo P, Fantini M . COVID-19 Vaccination in Pregnancy, Paediatrics, Immunocompromised Patients, and Persons with History of Allergy or Prior SARS-CoV-2 Infection: Overview of Current Recommendations and Pre- and Post-Marketing Evidence for Vaccine Efficacy and Safety. Drug Saf. 2021; 44(12):1247-1269. PMC: 8569292. DOI: 10.1007/s40264-021-01131-6. View